May 30, 2024

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You may not really know Fructose and xylitol

You may not really know Fructose and xylitol


You may not really know Fructose and xylitol. The more fruit is not the better, and the xylitol food is not unlimited intake.


You may not really know Fructose and xylitol


Fructose is a monosaccharide and is an isomer of glucose.



0 1 Fructose

Fructose is a simple sugar, an isomer of glucose, and is found in fruits, honey, sugary drinks, desserts and other foods.

Fructose is absorbed into the liver through the intestine, and a small amount of intake does not directly increase blood sugar.

Therefore, when blood sugar control is stable, diabetic patients can choose to eat a small amount of low-sugar fruit. But its metabolic process has no negative feedback regulation mechanism, that is to say, as long as there is a catalytic enzyme, no matter how much fructose is consumed, it can be broken down forever.


However, intermediate products such as uric acid and triose produced by the metabolism of fructose are the raw materials for lipid synthesis, which will cause the body to produce too much glucose, lactic acid, free fatty acids, triglycerides, very low density lipoproteins, diglycerides and other substances.

It is released into the systemic circulation and synthesizes fat in the liver, which can easily cause metabolic syndrome, diabetes, high blood pressure, fatty liver and other diseases.


Not only that, a large-scale prospective cohort study of 46,393 men without a history of gout found that the incidence of gout was 1.45 times that of 355 ml of 355 ml of sugary drinks per day.

The National Health and Nutrition Survey of the United States shows that the intake of fructose-rich beverages (whether artificial or natural) is associated with elevated blood uric acid levels.


While fructose increases the production of uric acid in the body, it also affects the excretion of uric acid. The intake of fructose-rich fruits is positively correlated with the increase in the incidence of gout.

It was found in healthy volunteers that fructose can reduce the uric acid clearance rate by 9.8%.


Therefore, in addition to controlling the intake of purines, people with hyperuricemia or gout should also control their intake of fructose.

Fruits with higher fructose content include apples, figs, oranges, grapefruits, lychees, persimmons, longans, bananas, bayberry, pomegranates and so on.



Patients with kidney disease should also control their intake of fructose.

A study of rats showed that compared with the glucose and normal diet groups, the rats fed the fructose diet had increased proteinuria, decreased creatinine clearance, and enlarged kidneys.

It suggests that fructose itself can induce and aggravate the progression of kidney disease.


Studies in rats have shown that fructose may reduce the sensitivity of the hypothalamus to leptin to reduce satiety after eating, thereby increasing caloric intake, leading to abdominal obesity and hypothalamic leptin resistance.

It can be understood that too much fructose intake will not make the eater feel full, and will easily lead to overeating.

Therefore, patients with overweight or obesity should not drink or drink less sugary drinks, eat less sweets, and reduce the intake of fructose-rich fruits.

At the same time, it is not recommended to use fruits instead of meals to lose weight.




0 2 Fructose syrup

There is a kind of sweetener called fructose syrup, which is often found in soft drinks, fruit drinks, desserts, ice cream and other foods.

It is a mixed syrup composed of glucose and fructose obtained through hydrolysis. The sweetness is close to the same concentration of sucrose. In terms of taste, the colder the sweeter.


Animal experiments have found that feeding mice with 15% fructose syrup water every day instead of drinking water will lead to metabolic disorders in mice and reduce their memory, learning and exercise abilities.


Develop healthy eating habits from an early age and reduce the intake of sugary drinks, desserts, and added sugars, which is an important factor in preventing childhood obesity and metabolic diseases in adulthood.


0 3 Xylitol

Xylitol is a natural five-carbon sugar alcohol. Its appearance and taste are similar to that of sucrose. Xylitol is 90 times sweeter than sucrose.

Without insulin promotion, xylitol can also be absorbed and utilized through cell membranes, making it the most common sugar substitute in diabetic foods. Ge Sheng et al. experimentally determined the GI value of xylitol to be 17.24±7.6.

Compared with maltose 105, glucose 100, sucrose 65, and fructose 23, its glycemic index is lower, which is suitable for diabetics.


Excessive intake of xylitol may cause gastrointestinal irritation, which may cause abdominal discomfort, flatulence, and bowel irritation.

In addition, because the absorption rate of xylitol in the intestine is less than 20%, it is easy to accumulate in the intestinal wall and easily cause osmotic diarrhea.

Research on drug resistance in healthy volunteers shows that oral administration of extremely high doses of xylitol (100 grams per day) can be tolerated by the human body, and no adverse reactions have been observed.

When the dosage is increased to 130 grams per day, diarrhea will occur.


Studies have also found that xylitol has the dual function of potentially increasing or decreasing blood sugar. Xylitol also needs the promotion of insulin in the later stage of metabolism.

If xylitol is applied in a large amount for a short time or a certain amount for a long time, the serum uric acid and oxalic acid levels can rise suddenly or slowly, and crystals are easily formed after the physiological saturation is exceeded. And damage the kidneys.

Therefore, when diabetics use xylitol as a sugar substitute, they must also control their intake and learn to stop.


Through the above analysis, we know that the more fruit is not the better, and the xylitol food is not unlimited intake.

Regardless of whether it is for healthy people or people with metabolic syndrome, in addition to the common white sugar that needs to be controlled, naturally occurring sugars (fructose) and food-added sugars (fructose syrup, xylitol) should be restricted on the amount. 






You may not really know Fructose and xylitol

(source:internet, reference only)

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Important Note: The information provided is for informational purposes only and should not be considered as medical advice.