June 29, 2022

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Can third-grade meningioma be cured?

Can third-grade meningioma be cured?

 

Can third-grade meningioma be cured? How to cure?

 

What is the grade of meningioma? Can third-grade meningioma be completely cured?

Can third-grade meningioma be cured? First of all, let’s get to know the brain tumor of meningioma. Meningioma is a relatively common type of primary brain tumor, accounting for about 30% of all brain tumors. It originates from the meninges, the three layers of protective tissue between the skull and the brain.

Meningioma grade (1 to 3) is based on the appearance of tumor cells under the microscope. Grade 1 is a very common type of meningioma and is considered benign. Grade 3 is the most aggressive form and is considered malignant.

The severity of meningioma depends on its grade (the following guidelines outline the meningioma grading system):

  • Grade 1 (benign): This non-cancerous brain tumor grows slowly and has clear boundaries. About 78% to 81% of meningiomas are benign (non-cancerous).
  • Grade 2 (atypical): Approximately 15% to 20% of meningiomas are atypical, which means that tumor cells will not appear typical or normal. Atypical meningiomas are neither malignant (cancerous) nor benign, but may become malignant at some point. Grade II meningiomas also tend to recur and grow faster.
  • Grade 3 (malignant or anaplastic): This aggressive brain tumor tends to invade the part of the brain closer to the tumor. Approximately 1% to 4% of meningiomas are grade III (cancerous).

   What kind of meningiomas are included? Tertiary meningioma usually includes papillary, rhabdoid, and anaplastic tumors. Usually the recurrence rate is high, and may metastasize to extracranial sites. The prognosis of anaplastic meningioma is poor, with a median overall survival (OS) of less than 1 year.

 

Can third-grade meningioma be cured? How to cure?

Generally speaking, the higher the grade of meningioma, the faster it grows, the more aggressive it is, and the easier it is to recur (meningiomas usually recur in situ). Grade 2 meningioma is low malignant, and grade 3 is malignant. The probability of metastasis is very low. Generally, don’t worry about metastasis. Survival depends on surgery and postoperative chemotherapy.

Before the middle of the 20th century, the world did not have enough understanding and unified understanding of the biological characteristics of meningiomas and the many factors affecting its recurrence. Since then, it has been verified by many relevant studies that the safest possible removal of meningioma can prolong progression-free survival without increasing the complication rate. This confirms the internationally accepted Simpson grading system for surgical resection of intracranial meningioma.

 

The current internationally accepted Simpson classification predicts the relationship between meningioma recurrence

The INC International Neurosurgeon Group finally pointed out that the anatomical location of meningiomas is related to its recurrence rate.

The more difficult it is to completely remove a certain part of the tumor, such as castellated meningioma, the greater the possibility of recurrence. If meningiomas invade the venous sinuses, such as parasagittal meningiomas, the recurrence rate is higher.

The recurrence rate of meninges is different in different research series; the recurrence rate of sphenoid crest meninges is the highest (>20%), followed by parasagittal meninges (8%-24%). The recurrence rates of convex and suprasellar meningiomas were 5% and 10%, respectively.

 

(source:internet, reference only)


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