Cancer is the fourth leading cause of death among adolescents and young people worldwide

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Cancer is the fourth leading cause of death among adolescents and young people worldwide

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Lancet Oncology: Cancer is the fourth leading cause of death among adolescents and young people worldwide.

The global burden of cancer in adolescents and youth in 2019: A systematic analysis of the global burden of disease research in 2019.

Background :

When estimating the global cancer burden, although adolescents and young people are a unique subgroup with unique epidemiology, clinical care needs, and social impact, they are often overlooked.

There is a lack of comprehensive estimates of the global cancer burden for adolescents and young adults (15-39 years of age).

To bridge this gap, we analyzed the results of the 2019 Global Burden of Disease, Injury, and Risk Factors Study (GBD), focusing on the results of the Disability-Adjusted Life Year (DALY), and providing information for adolescents and young people on global cancer control measures .

Methods :

Using the GBD 2019 method, international mortality data were collected from vital registry, autopsy, and population-based cancer registry inputs, and these data were modeled on mortality and morbidity (MIR).

Use mortality estimates and the corresponding MIR to calculate the incidence.

Use the modeled survival rate to calculate the prevalence estimate and multiply it by the disability weight to obtain the number of years of life with disability (YLD). Years of Life Lost (YLL) is calculated as the standard life expectancy of the number of cancer deaths at a specific age multiplied by the age of death.

The main result is DALY (the sum of YLL and YLD). Estimates are presented globally in the sociodemographic index (SDI) quintile (countries are ranked and divided into five equal SDI groups), and all estimates are presented in the corresponding 95% uncertainty interval (UI).

Findings :

In 2019, there were 11,900 (95% UI: 1.11-1.28) cancer cases and 396,000 (370,000-425,000) deaths from cancer among 15-39 year-olds worldwide.

Standardized incidence rates occur in high SDI (59.6 [54.5-65.7] per 100,000 person-years) and medium-to-high SDI countries (53.2 [48.8-57.9] per 100,000 person-years), while the highest age-standardized mortality rate is low-medium SDI ( 14.2 [12.9-15.6] per 100,000 person-years) and medium SDI (13.6 [12.6- 14.8] per 100,000 person-years) countries.

2019, adolescents and young cancer contributions to the global burden of disease of 23.500 Wan (21.9-25.2) DALY, of which 2.7% (1.9-3.6) from YLD , 97.3% (96.4-98.1) from YLL . Cancer is the first global adolescents and young adults died four big reason and DALY of ten major reason.

Conclusion :

In 2019, cancers in adolescents and young adults made a significant contribution to the global burden of disease in adolescents and young adults.

These results provide new insights into the distribution and scale of the global burden of cancer in adolescents and young adults.

Because of the significant differences observed in SDI settings, these estimates can inform global and national cancer control efforts.

Lancet Oncology: Cancer is the fourth leading cause of death among adolescents and young people worldwide.

(source:internet, reference only)

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