September 25, 2022

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Parents received COVID-19 vaccines also provide substantial protection for children

Parents received COVID-19 vaccines also provide substantial protection for children



 

Science: Parents received COVID-19 vaccines also provide substantial protection for children.


In a new study, researchers from Israel’s Claret Institute, Tel Aviv University, and Harvard University analyzed one of the world’s largest databases of comprehensive health records to study the risk of parental vaccination against BNT162b2 (Pfizer) for the future Indirect protection provided by vaccinated children.

Related research results were published online in the journal Science on January 27, 2022, with the title ” Indirect protection of children from SARS-CoV-2 infection through parental vaccination “.


Between June 2021 and October 2021, a wave of infections dominated by the Delta variant of SARS-CoV-2 swept Israel.

During this period, the authors studied 181,307 unvaccinated children from 76,621 different households and compared parents who received a third dose of the vaccine (a booster) with those who had only received two doses at least five months earlier. parents to compare.

The study estimated that booster vaccination with only one parent reduced the risk of infection in children by 20.8% (95% confidence interval: 11.4% to 29.1%), while booster vaccination with both parents reduced the risk of infection in children 58.1% (95% confidence interval: 53.1% to 62.6%).


The authors also conducted similar studies during an earlier wave of alpha variants predominant between December 2020 and March 2021.

During this period, they studied 400,733 unvaccinated subjects (children and adolescents) from 155,305 different households.

They compared unvaccinated parents with parents who received two doses of the vaccine and found that parental vaccination had even stronger indirect protection for children than the above.


Looking at specific groupings, the authors found that the indirect effects of parental vaccination were fairly consistent across household sizes and children of all ages, including those 0-2 and 3-6 years who are currently still ineligible for the vaccine. youngest age group.


Parents received COVID-19 vaccines also provide substantial protection for children.
Mechanism of disease transmission, image from Science, 2022, doi:10.1126/science.abm3087.

 


The study further explores the mechanism of this indirect effect, showing that vaccinated parents are not only less likely to have a documented infection, but if they become infected, they are also less likely to transmit the infection to other family members.


Taken together, the findings of this study suggest that parental vaccination provides substantial protection for children living in the same household.

These results reinforce the importance of increasing vaccination rates among vaccinated populations to contain the spread of the SARS-CoV-2 pandemic and protect those who cannot.


” Not only does vaccination provide direct protection, it also provides indirect protection for unvaccinated people who live in the same household as the vaccinated person ,” said first author Samah Hayek, Ph.D., senior research fellow at the Clarett Institute .

The indirect protection that vaccinated parents provide to their unvaccinated children, regardless of family size or the age of the child, is true for both Alpha and Delta variants. ”


“While the age range for vaccination continues to expand, many children and adolescents remain unvaccinated for different reasons,” said Noam Barda, Ph.D., corresponding author of the paper and head of epidemiology and research at the Clarett Institute. The new study showed that parental vaccination provided substantial protection to children living in the same household, underscoring that vaccination protects not only the recipient but also their loved ones. “


Co-author Professor Ran Balicer, Director of the Clarett Institute, said: “This study of Clarett Institute data shows that vaccinated and booster-vaccinated parents provide their unvaccinated children with an effective dose of COVID-19. 19 Protection.

By quantitatively determining indirect protection provided from vaccinated parents to unvaccinated children, these authors identified several mechanisms of protection, including breakthrough infections from vaccinated parents compared with unvaccinated parents The rate of transmission to their unvaccinated children was lower.”


“This is yet another example of the kind of rich and complete data maintained by the Clarett Institute for answering important scientific and public health issues,” said co-author Professor Marc Lipsitch, director of the Center for Infectious Disease Dynamics at the Harvard T.H. Chan School of Public Health. The value of the question. Knowing that getting vaccinated not only protects the recipient but also protects their families, any parent who is indecisive should be encouraged to get vaccinated and, when appropriate, get a booster vaccine.”


Co-author Professor Ben Reis, director of the Predictive Medicine Unit at Harvard Medical School, said, “Parents have a profound responsibility to protect their children from harm. Especially in families where children are too young to be vaccinated, this study provides There is stark evidence of the importance of parental vaccinations – not only to protect themselves, but also their children.”


Co-author Dr Daniel Nevo, Senior Lecturer in Statistics and Operations Research at Tel Aviv University, said, “The results of this study exemplify how to elucidate causal questions and answer them with the right methodology and rich data, leading to valuable answers. We are now one step closer to understanding the impact of a large-scale vaccine.”

 

 

 

 


Reference:
Samah Hayek et al. Indirect protection of children from SARS-CoV-2 infection through parental vaccination. Science, 2022, doi:10.1126/science.abm3087.

Science: Parents received COVID-19 vaccines also provide substantial protection for children.

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