September 28, 2022

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Nature: Mitochondrial fission requires protein DRP1 but not dynein

Nature: Mitochondrial fission requires protein DRP1 but not dynein



 

Nature: Mitochondrial fission requires protein DRP1 but not dynein


Mitochondrial fission (sometimes translated as mitochondrial fission) is required for the maintenance of the mitochondrial network and depends on a GTPase called dynamin-related protein 1 (DRP1, also known as DNM1L). DRP1 forms helical oligomers that wrap and split the mitochondrial outer membrane.

Recently, it has been suggested that DRP1 is insufficient for mitochondrial fission and that another GTPases called dynein-2 (dynamin-2, DNM2, also known as DYN2) are essential components of the mitochondrial fission complex.

 

In a new study, researchers from the University Medical Center Göttingen, Germany report that mouse fibroblasts (hereafter referred to as dynein triple knockout cells) lack all three mammalian dyneins (DNM1, DNM2, and DNM3). ) and DNM2-only knockdown cells exhibited neither mitochondrial fission or hyperfusion defects, but knockdown of DRP1 readily detected these defects, even in dynein triple-knockout cells.

The relevant research results were published in the journal Nature on June 20, 2019, and the title of the paper is “Mitochondrial fission requires DRP1 but not dynamins”.

 

Nature: Mitochondrial fission requires protein DRP1 but not dynein

Image from Nature, 2019, doi:10.1038/s41586-019-1296-y.

 

Given that mitochondria and peroxisomes share the same fission mechanism, the researchers studied peroxisome fission and observed the same situation as mitochondrial fission.

 

Thus, these findings suggest that DRP1 is essential for mitochondrial and peroxisomal fission, whereas mammalian dyneins DNM1, DNM2, and DNM3 are not.

 

 

 

 

Reference:
Tiago Branco Fonseca et al. Mitochondrial fission requires DRP1 but not dynamins. Nature, 2019, doi:10.1038/s41586-019-1296-y.

Nature: Mitochondrial fission requires protein DRP1 but not dynein

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