Pregnant women received mRNA vaccine will pass antibodies to their children and remain for at least 6 months

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Pregnant women received mRNA vaccine will pass antibodies to their children and remain for at least 6 months

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JAMA: Pregnant women received mRNA vaccine will pass antibodies to their children and remain for at least 6 months.

As the COVID-19 pandemic enters its third year, efforts to mitigate the risk of infection remain critical, especially for vulnerable groups.

Recently, Andrea Edlow of Massachusetts General Hospital and others published a research paper titled: Durability of Anti-Spike Antibodies in Infants After Maternal COVID-19 Vaccination or Natural Infection in the journal JAMA .

The study showed that vaccination during pregnancy resulted in longer-lasting infant antibody levels than infants born to unvaccinated and COVID-19-infected mothers .

The study included individuals who received two doses of the mRNA vaccine or were infected between 20 and 32 weeks of gestation , when antibody transfer across the placenta had peaked. The research team found that at 6 months, protective antibody levels were detectable in infants born to vaccinated mothers, while unvaccinated or Covid-19-infected mothers had levels of antibodies at birth and in infants. Either titer or antibody levels are low.

Andrea Edlow, Ph.D., the study’s corresponding author, a maternal-fetal medicine specialist at Massachusetts General Hospital and director of the Edlow Laboratory at the Vincent Center for Reproductive Biology, said that while it’s unclear what titers are needed to fully protect infants from the new coronavirus, But we do know that levels of anti-spike protective immunoglobulin G (anti-spike IgG) correlate with protecting infants from severe disease.

Dr. Andrea Edlow, Maternal Fetal Medicine Specialist, Massachusetts General Hospital, Director of Edlow Laboratory, Vincent Center for Reproductive Biology

Titers, or antibody levels, in the cord blood of vaccinated mothers and their delivery were higher than those of study participants who were infected with COVID-19.

After two months, 98 percent (48 of 49) of babies born to vaccinated mothers had detectable levels of protective immunoglobulin G (IgG) , the most common antibody in the blood.

After 6 months, the researchers examined 28 infants born to vaccinated mothers and found that 57 percent (16 of 28) still had detectable IgG. In contrast, only 8 percent (1 in 12) of babies born to infected mothers .

Dr. Andrea Edlow said: “While it is unclear what titers are required to fully protect infants from Covid-19, we do know that levels of anti-spike IgG are associated with protection against infants from SARS-CoV-2. Injury related to serious illness.

Durability studies of antibody responses showed that vaccination not only provided durable protection for mothers, but antibodies persisted in most infants until at least 6 months of age. Many from parents to pediatricians have wondered how long a mother’s antibodies can last in a baby’s body after vaccination, and now we can provide some answers.

We hope these findings will further motivate pregnant women to get vaccinated, especially with the emergence of worrisome new variants like Omicron.

Study co-first author Dr. Galit Alter , a core member of the Ragon Institute at MIT and Harvard , said pregnant women are at extremely high risk for severe complications from COVID-19.

Given the lag in the development of a COVID-19 vaccine for infants, these data should prompt mothers to get vaccinated during pregnancy, or even boost it, to boost their infants’ defenses against COVID-19.

References :
https://jamanetwork.com/journals/jama/fullarticle/2788986?resultClick=3
https://www.massgeneral.org/news/press-release/Study-shows-persistent-antibodies-in-infants-after-covid-19-vaccination-in-pregnancy

JAMA: Pregnant women received mRNA vaccine will pass antibodies to their children and remain for at least 6 months.

(source:internet, reference only)

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