June 29, 2022

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What is the relationship between Antihypertensive drugs and COVID-19 risk?

What is the relationship between Antihypertensive drugs and COVID-19 risk?



 

What is the relationship between Antihypertensive drugs and COVID-19 risk?


The initial hypothesis was that the use of inhibitors of the renin-angiotensin-aldosterone system was positively associated with the risk of COVID-19 pneumonia (COVID-19) , but recent evidence suggests an inverse association.

Recently, a research article was published in Hypertension, an authoritative cardiovascular journal.

The researchers aimed to investigate the use of angiotensin-converting enzyme inhibitors (ACE) and angiotensin receptor blockers compared with calcium channel blockers (CCBs).

Whether the risk of COVID-19 in patients treated with antihypertensive drugs (ARBs) varies by class of antihypertensive drugs.

 

What is the relationship between Antihypertensive drugs and COVID-19 risk?

 

From February 15, 2020 to June 7, 2020, the researchers followed 3 cohorts in the French National Health Insurance database, ACE inhibitor, ARB and CCB users, aged 18 to 80 years .

The researchers excluded patients with a history of diabetes, cardiovascular disease, chronic renal failure, or chronic respiratory disease within the past 5 years, and only considered patients with uncomplicated hypertension.

The primary endpoint of the study was length of stay for COVID-19. A secondary endpoint was time to intubation/death during hospitalization for COVID-19.

 

What is the relationship between Antihypertensive drugs and COVID-19 risk?

 

In a population of nearly 2 million hypertensive patients (ACE inhibitors: 566,023; ARB: 958,227; CCB: 358,306), 2,338 were hospitalized and 526 died or intubated due to COVID-19 during 16-week follow-up.

ACE inhibitor users and ARB users had a lower risk of COVID-19 hospitalization compared with CCBs users (hazard ratio 0.74 [95% CI 0.65-0.83] and 0.84 [0.76-0.93], respectively), intubation/ Lower risk of death. Patients using ACE inhibitors had a slightly lower risk than those using ARBs.

 

This large observational study may suggest that hypertensive patients treated with long-term ACE inhibitors or ARBs have a lower risk of COVID-19 compared with CCBs.

 

 

 

 

 

 

Reference:

Laura Semenzato.et al.Antihypertensive Drugs and COVID-19 Risk A Cohort Study of 2 Million Hypertensive Patients.Hypertension.2021.https://doi.org/10.1161/HYPERTENSIONAHA.120.16314

What is the relationship between Antihypertensive drugs and COVID-19 risk?

(source:internet, reference only)


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