Immune Evasion and Pulmonary Viral Load in Omicron Mixed Subtype XE
- The new coronavirus may kill cancer cells and achieve a permanent cure!
- Why did the Alzheimer’s drug candidate BACE1 inhibitor fail?
- LRTI Death: Research spanning 80 years confirms for the first time
- The decline of the global antibiotic market is threatening the development of new drugs
- World first: An mRNA vaccine that can 100% protect against deadly bacterial infections is available
- The first successful use of CAR-T cells to treat severe muscle inflammation
Immune Evasion and Pulmonary Viral Load in Omicron Mixed Subtype XE
- More than 1 million Chinese died after China quit “Zero-COVID policy”?
- Why is Vinyl chloride listed as a Class A “known human carcinogen” ?
- First human trial of HIV gene therapy: A one-time cure will be achieved if successful!
- New breakthrough in CAR-T cell therapy: Lupus erythematosus patients achieved treatment-free remission for up to 17 months
- How long can the patient live after heart stent surgery?
- First time: Systemic multi-organ recovery after death
Nature Preprint: Immune Evasion and Pulmonary Viral Load in Omicron Mixed Subtype XE
On April 4, 2022, the Nature preprint database published research from the Pasteur Institute in France, reporting XD, the virological characteristics of Delta-Omicron recombinant subtypes [1].
Research shows:
- This strain of immune escape is characterized by Omicron BA.1, which binds ACE2 more like Delta in hACE2 mice .
- Viral loads in the lung and nose were lower than Delta and close to Omicron.
Cov-lineages.org shows that in fact all subtypes starting with X indicate “recombinant” virus serotypes .
Except for XA, XB, XC, all subtypes from XD all the way up to XS are recombinant serotypes of Omicron . That is to say, since the appearance of Alpha mutants, most of the recombinant types are formed between Omicron and other serotypes or subtypes within Omicron.
This suggests that superinfection of Omicron is much more common than other mutant strains.
In epidemiology, if a patient is infected with a pathogen, the infection is cured, and then a de novo infection with the pathogen occurs is called a superinfection .
If the infection is still in progress, the same pathogen re-invades and causes infection, which is called superinfection . Superinfection is the mechanism by which many viruses recombine to form new virus subtypes.
Omicron is easy to form superinfection, which is due to its special RBD and Spike structure , so that the neutralizing antibodies after infection by other popular strains cannot effectively neutralize Omicron, so superinfection is more likely to occur.
However, the Spike of SARS-CoV-2 is the main protein that determines its ability to spread and infect cells. Therefore, it can be predicted that the recombinant type carrying BA.2 Spike has an absolute transmission advantage .
But it is difficult to predict whether these recombinant subtypes will overtake the original single subtype and form new epidemics. This requires virological experiments to judge.
References:
1. https://www.researchsquare.com/article/rs-1502293/v1
Immune Evasion and Pulmonary Viral Load in Omicron Mixed Subtype XE
(source:internet, reference only)
Disclaimer of medicaltrend.org