Researchers finds new way cancer cells repair DNA damage
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Researchers finds new way cancer cells repair DNA damage.
Researchers at the University of Birmingham have discovered a new way cancer cells repair DNA damage.
These new findings reveal new responses of cancer cells to chemotherapy and radiotherapy, as well as new ways in which cancers develop resistance to targeted therapies.
These insights may help clinicians decide on different cancer treatments that can be more targeted to specific patients.
Repairing DNA damage is essential for cells to stay healthy and prevent diseases such as cancer.
Understanding how DNA repair works is critical to better understanding how cancer develops and how to effectively use anticancer treatments such as radiation and chemotherapy to induce DNA damage that can kill cancer cells.
In the study, published May 19, 2022 in the journal Molecular Cell, a team from the university’s Institute for Cancer and Genome Sciences pinpointed two proteins previously undiscovered in DNA repair .
These proteins, called SETD1A and BOD1L, modify other proteins called histones, which bind to DNA.
Removing these two proteins changes how DNA is repaired and makes cancer cells more sensitive to radiation therapy.
Losing SETD1A and BOD1L also makes cancer cells resistant to certain anticancer drugs called PARP inhibitors.
Lead author Associate Professor Martin Higgs explained.
“This is the first time that these genes have been directly linked to DNA repair in cancer. This research has the potential to change the way cancer patients are identified for treatment and how they develop resistance to different drugs, which will improve treatment efficiency and patient outcomes”.
The team hopes that the work will eventually also allow new inhibitors to be developed, allowing clinicians to resensitize cancers that have become resistant to certain therapies.
Researchers finds new way cancer cells repair DNA damage
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