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How to speed up muscle tissue repair?
How to speed up muscle tissue repair? A study led by researchers from the School of Engineering at the University of California, San Diego provides new insights into the development of treatments for muscle diseases, injuries and atrophy. By studying how different pluripotent stem cell lines build muscle, researchers have discovered for the first time how to trigger epigenetic mechanisms at different stages of stem cell differentiation to accelerate muscle cell growth.
The results of the study were published in the journal Science Advance on March 17.
“Stem cell-based methods may help muscle regeneration and growth, and will improve the quality of life of many people, from children with congenital muscle diseases to people who have lost muscle mass and strength due to aging,” the author of the article, Shankar Subramaniam The professor said: “Here, we found that we can use external means to trigger specific factors and mechanisms that are conducive to rapid growth.”
The researchers used three human induced pluripotent stem cell lines and studied how they differentiate into muscle cells. Among the three, the fastest growing of a cell line is muscle. Researchers studied what factors make this line different from other lines, and then induced these factors in other lines to see if they can accelerate muscle growth.
They found that triggering several epigenetic mechanisms at different points in time accelerates muscle growth in “slow” pluripotent stem cell lines. These measures include suppressing a gene called ZIC3 at the beginning of differentiation, and then adding a protein called β-catenin transcription cofactor later in the growth process.
Subramaniam said: “A key point is that all pluripotent stem cells have different regenerative capabilities.” “Identifying the factors that will initiate specific regeneration of these cells will go a long way in regenerative medicine.”
Next, the research team will explore therapeutic interventions such as drugs that can stimulate and accelerate muscle growth at different stages of human-induced pluripotent stem cell differentiation. They will also observe whether implanting specific pluripotent stem cells in malnourished muscles can stimulate the growth of new muscles in animals. Ultimately, they hope to understand whether this stem cell-based method can regenerate muscle in aging humans.
(source:internet, reference only)