Small wireless device implanted between skin and skull helps kill cancer cells
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Small wireless device implanted between skin and skull helps kill cancer cells.
Brain cancer is one of the most insidious forms of the disease, but researchers at Stanford University have now developed a wireless device that could help improve survival times.
When implanted between the skin and skull, the remotely activated device heats the gold nanoparticles, killing cancer cells from the inside.
Glioblastoma is an aggressive cancer with a five-year survival rate of only 5%.
It is usually treated with surgery to remove the tumor, followed by radiation or chemotherapy to remove any remaining cells. Unfortunately, this cancer often recurs in forms that are resistant to these treatments.
But in a new study, scientists at Stanford University have developed a less invasive approach to treating brain tumors that, in tests in mice, dramatically increased survival times. Just 15 minutes of treatment a day for 15 days, even when the mice were just doing their usual things.
The technology works on an emerging approach to treating various types of cancer that involves injecting nanoparticles into tumors and then triggering them to heat up. T
riggers can take the form of electromagnetic fields, ultrasound or light, and since cancer cells are more sensitive to heat than healthy cells, this can kill them with minimal damage to surrounding tissue.
Stanford’s new device is designed to be implanted between the skin and the skull and emits infrared light when turned on.
Star-shaped nanoparticles made of gold are injected into brain tumors through a small hole in the skull, and infrared light from the device heats them to as much as 5°C.
After several rounds of such treatments, the cancer cells were successfully killed.
Adjusting the power of the infrared energy, as well as the wavelength of the light, allowed them to target tumors of different sizes and different locations within the brain, the team said.
In tests on mice, the scientists found that the treatment reduced cancer cells in the brain and greatly extended the animals’ lifespans — on average, three times as long as untreated mice. When chemotherapy was added to this combination, the mice survived even longer.
Although the research looks promising so far, it is of course difficult to extrapolate its results to humans. But the team hopes to scale up the device for use in human patients as another weapon against this deadly form of cancer.
The research was published in the journal Nature Nanotechnology.
Small wireless device implanted between skin and skull helps kill cancer cells
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