Does Vitamin D Supplementation Work?

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Does Vitamin D Supplementation Work?

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Does Vitamin D Supplementation Work? Effects May Depend on Your Weight, New Study Shows.

Vitamin D is an essential nutrient involved in many biological processes, most notably helping our bodies absorb minerals such as calcium and magnesium.

There are two main ways for the human body to obtain vitamin D, one is to bask in the sun, and the other is through food intake.

Vitamin D is mainly found in sea fish, animal liver, egg yolk and lean meat. An estimated 30%-60% of the world’s population is vitamin D deficient or deficient, but vitamin D deficiency can often be treated with supplements.

Multiple evidences from play a role in the occurrence and progression of cancer and cardiovascular diseases , and vitamin D has also been used for the prevention and treatment of bone-related diseases for a long time. disease. However, the health benefits of vitamin D supplementation have been debated.

This prompted the initial VITAL trial. This is a randomized, double-blind, placebo-controlled trial involving 25,871 U.S. participants, including men over 50 years of age and women over 55 years of age, investigating whether taking vitamin D or Omega-3 supplements can reduce risk of disease. Risk of cancer, heart disease, stroke and many other diseases.

Published results from the VITAL trial showed that while vitamin D supplementation had little benefit in preventing cancer, heart attack, or stroke across the cohort, body mass index (BMI) was associated with cancer incidence, cancer mortality, and autoimmune disease incidence.

There was a statistical correlation between the rates, and other studies have shown similar results for type 2 diabetes.

To investigate the reasons behind this correlation, a research team at Harvard Medical School’s Brigham and Women’s Hospital conducted a new study based on data from the VITAL trial.

Their analysis of the raw VITAL data found that vitamin D supplementation was associated with positive effects on several health outcomes, but only in those with a BMI below 25 (that is, those who were not overweight and obese) . Vitamin D metabolism appears to be altered at higher BMI.

The study offers a possible explanation for the conflicting conclusions of previous vitamin-related studies and suggests that BMI should be taken into account when assessing the health effects of supplements.

Based on the VITAL trial, researchers analyzed data from 16,515 participants in the original trial who provided blood samples at baseline (before randomization to each treatment group) and 2,742 of whom were followed up two years later blood sample sampling.

The researchers measured blood levels of total and free vitamin D, as well as many other novel biomarkers of vitamin D, such as its metabolite calcium and parathyroid hormone (PTH) , which helps the body utilize Vitamin D.

The analysis of the studies found that the higher the BMI of the participants, the lower the total serum 25-hydroxyvitamin D (25-OHD) levels before randomization.

Likewise, levels of 25-OHD3, free vitamin D (FVD) , bioavailable vitamin D (BioD) , vitamin D-binding protein (VDBP) , albumin, and calcium all decreased with increasing BMI, while parathyroid Higher hormone levels.

Vitamin D supplementation increased blood levels of total 25-OHD, 25-OHD3, FVD, and BioD in participants compared with the placebo group, but this increase was significantly lower in participants with a higher BMI.

Furthermore, vitamin D supplementation did not substantially alter VDBP, albumin, parathyroid hormone, or calcium levels.

Deirdre K. Tobias , lead author of the paper, said: “We observed a significant difference two years after the trial, suggesting that people with higher BMIs were less responsive to vitamin D supplementation, which may have clinical implications and may explain the obesity status.” Some observed differences in the effectiveness of vitamin D supplements.

Previously, most similar studies focused on total vitamin D levels in the blood, and this study additionally focused on vitamin D metabolites and related novel biomarkers, which provide insights into vitamin D activity and availability in the body.

More insights. The findings suggest that vitamin D metabolism may be disrupted in people with a higher BMI but not in others.

Corresponding author JoAnn E. Manson said this study reveals why we see a 30%-40% lower risk of cancer death, autoimmune disease and other diseases after vitamin D supplementation in people with lower BMI, but in people with lower BMI.

There was little benefit in those with high levels of vitamin D, suggesting that it may be possible to achieve benefits across the population through more individualized vitamin D dosing.

The findings of this study call for the research community to continue exploring the potential benefits of vitamin D supplementation for the prevention of cancer and other diseases, and to consider BMI when assessing the effects of supplementation on health.

Paper link :
https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2800490

Does Vitamin D Supplementation Work?

(source:internet, reference only)

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