Renowned Queen’s Music Can Shake Up Insulin Cells?!
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Renowned Queen’s Music Can Shake Up Insulin Cells?!
Perhaps a bit sensational, but many people claim that rock music has saved their lives. Now, new research suggests that this genre of music might truly be a lifeline for diabetes patients.
In the United States alone, over 37 million people suffer from diabetes, a condition characterized by a lack of insulin production within the body.
As a result, diabetes patients often rely on insulin supplementation, typically administered through injections, which can be painful and inconvenient.
Researchers have been on a quest to find alternative ways to enhance insulin levels in diabetes patients.
Earlier this year, we saw a study exploring the development of edible insulin, and previous research has explored methods ranging from implantable devices similar to tea bags to hormone-releasing patches.
However, none of these methods quite compare to a groundbreaking study from the Swiss Federal Institute of Technology (ETH) in Zurich.
Researchers at ETH Zurich extracted a protein from Escherichia coli (E. coli) bacteria, a protein capable of controlling the flow of calcium ions within bacterial cells. They then implanted this protein into human insulin-producing cells, endowing these cells with ion channels.
Subsequently, they discovered that when exposed to sound environments, these engineered cells allowed positively charged calcium ions to enter, forcing the insulin they contained to fuse with the cell membrane and release externally, where it could be distributed throughout the body.
While some researchers might have stopped at using a tone generator to orchestrate insulin release from the cells, the Zurich team took it a step further – they used rock music.
Regarding bass:
The research team found that ion channels operated most effectively at 60 decibels (dB) of volume and a low-frequency bass of 50 hertz.
They also found that for maximum insulin release, the sound needed to play for no less than three seconds with pauses not exceeding five seconds.
They implanted the engineered cells into mice and positioned the mice belly-down on top of speakers.
They then played a variety of different songs and charted their effects. Heavy bass rock music triggered the best response, with Queen’s “We Will Rock You” releasing approximately 70% of insulin in just five minutes, and the entire insulin payload within 15 minutes.
This song registered at 85 dB, similar to what most people have for home stereo setups. The soundtrack of Marvel’s “The Avengers” ranked second. Music with less bass, such as classical and acoustic guitar pieces, had much weaker effects.
To trigger insulin release, the implanted cells had to be directly above the sound source. Earplugs or headphones had no effect.
Additionally, ambient noise in the environment did not affect the cells, which serves as an inherent safety feature of the design, as releasing insulin due to environmental noise could be dangerous.
Currently, researchers view this experiment as a proof of concept.
They state that any kind of sound-triggered insulin release system is still a long way off and would require commercial interest to become a reality. Scientists also note that this discovery could be applied to other types of cells to treat a range of diseases.
The research findings have been published in The Lancet journal.
Renowned Queen’s Music Can Shake Up Insulin Cells?!
(source:internet, reference only)
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