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Pfizer: Neutralization effect of 3 doses (vaccines) 100 times more against Delta variant

Pfizer: Neutralization effect of 3 doses (vaccines) 100 times more against Delta. Booter shot will provide much stronger protection against DElat variant according the data released by Pfizer on July 28.

Pfizer posted these data online on July 28. These data show that the antibody levels against Delta varant after receiving 3rd dose of COVID-19 are much higher comparing with the antibody level with 2 doses among people aged 19-55.

Among people aged 65 to 85 after receiving the 3rd dose, the level of antibodies against the Delta variant after receiving the third dose of vaccine is more than 11 times higher than the antibody level after the second dose of vaccine.

The researchers wrote in Pfizer’s data slide: It is estimated that the neutralization effect of Delta variant after the third dose may increase by 100 times compared with that before the third dose.

These data have not been peer reviewed or published.

The data also shows that for the original coronavirus variant and the Beta variant first discovered in South Africa, the antibody level after the third dose is also much higher than the second dose.

Pfizer: Neutralization effect of 3 doses (vaccines) 100 times more against Delta

3rd dose (booster shot) of COVID-19 vaccine is really necessary ?

As the delta strain of the mutated COVID-19 virus is raging around the world, most parts of the world are still shrouded in the shadow of the epidemic. Some countries have announced or are considering introducing COVID-19 vaccines for some people. Three doses of strengthening shots. However, some researchers said that although the third booster shot can enhance the immune response, it is not necessary. Whether or not to get the third dose of enhanced injection has become a topic of discussion among governments and scientific research circles in various countries.

Why do you need a booster shot? This is because the protective effect of certain vaccines may weaken over time. In order to provide additional protection, it is necessary to re-vaccinate to stimulate the body to produce and increase antibody levels. For many vaccines to prevent viral infections, booster shots are common, such as the flu vaccine that is boosted once a year.

Another reason people may need to get a booster shot of the COVID-19 vaccine is virus mutation. A spokesperson for the COVID-19 Vaccine Group at Oxford University in the United Kingdom said that some mutant strains have evolved to avoid part of the human immune response, which means they can more easily infect people who have recovered from the new coronavirus or have been vaccinated. However, the virus cannot avoid all immune responses in the human body. A booster shot is helpful, because it can increase the immune response that the mutant strain cannot avoid.

There is also a view that booster shots may be beneficial to the elderly or people with weakened immune systems, because their bodies may not have a strong enough immune response after the earlier vaccination, but evidence is still needed to prove that they are given to these people. Strengthening needles are safe and effective.

Pfizer Pharmaceuticals Co., Ltd. of the United States and New Biotechnology Corporation of Germany issued a joint statement on July 8, stating that the third booster shot of Pfizer vaccine (BNT162b2) is expected to help the human body to improve the human body’s exposure to multiple mutated new coronaviruses including the Delta strain. Resilience.

The statement said that preliminary data from the trial of the third dose of the vaccine showed that the human body injected the third dose 6 months after the second dose, and the body’s level of neutralizing antibodies against the new coronavirus and mutant virus beta strains was higher than that of the two doses. Increase 5 to 10 times.

According to the statement, data from a recent paper published in the British journal Nature showed that the test found that the human body had a higher level of neutralizing antibodies to the Delta strain after the second dose of Pfizer vaccine. The two companies expect that the third dose will further increase the level of such antibodies, which is currently being verified through preclinical and clinical trials.

According to data previously released by the Israeli Ministry of Health, the protective effect of Pfizer vaccine has declined 6 months after vaccination, but it still has a significant effect in preventing severe illness. Based on existing data, the two companies believe that it may be necessary to inject a third dose within 6 to 12 months after the completion of the two doses of vaccination to continue to provide protection for the human body. The Israeli Ministry of Health has announced on July 12 that it will provide a third dose of the COVID-19 vaccination for people with low immunity in the country.

With the increase in the number of people who have completed the two doses of vaccination, the British government has also begun to consider implementing the third dose booster plan as soon as possible. According to the news released by the British Ministry of Health on June 30, the “Joint Committee on Vaccination and Immunization” of the independent government expert group recommended that the most susceptible population be given a third booster injection in September, so as to strengthen the treatment before this winter. Protection of some people.

But the British Ministry of Health also said that as data analysis continues, the final recommendations of the committee may change. The United Kingdom is currently evaluating the effect of the COVID-19 vaccine booster through clinical trials. It is expected that the research team will announce the preliminary results of this clinical trial in September this year.

A preprinted paper published by the US “Social Science Research Network” not long ago stated that Oxford University researchers used AstraZeneca vaccine as the research object and found that the third dose of the vaccine can greatly enhance the immune response. But they also said that there is currently no indication that a third booster shot is needed, and they emphasized that the “priority” is to ensure that people all over the world get the first dose of vaccine.

The World Health Organization also stated that there is currently insufficient evidence to show that a third dose of vaccine is needed. Pharmaceutical companies such as Pfizer in the United States should focus on providing vaccines to countries that do not have the opportunity to obtain the first dose of vaccines, rather than boosting vaccines for those already vaccinated in wealthy countries.

Jay Butler, deputy director of the US Centers for Disease Control and Prevention in charge of infectious disease prevention, believes that for those who have been fully vaccinated, the third dose of the vaccine may bring a higher risk of adverse reactions. However, there is not enough data at this stage to determine whether this will happen.

The U.S. Centers for Disease Control and the U.S. Food and Drug Administration issued a joint statement on July 8 stating that Americans who have completed two doses of vaccinations do not need to receive the third dose at the moment, but if it is scientifically proven that an intensified injection is indeed needed, these two departments Also “ready.” Subsequently, the European Medicines Agency also issued a document saying that it is “too early” to determine whether and when the third dose of vaccine is needed.

　　Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, said on July 11, “Given the data and information we currently have, we don’t need to vaccinate the people with the third dose (COVID-19 vaccine).” “About whether and When should the intensive injection be given, a number of studies are now being carried out.”

Pfizer: Neutralization effect of 3 doses (vaccines) 100 times more against Delta

(source:internet, reference only)

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