The latest guidance on how to exercise safer for diabetics

The latest guidance on how to exercise safer for diabetics.   Viral load is the most important transmission factor. New DARPin drugs bring hope, “good” cholesterol is associated with low risk.

New DARPin drugs may be better than antibody drugs

Researchers recently published a report on medRxiv that the new DARPins drugs may be superior to monoclonal antibodies in neutralizing the coronavirus, even if the virus mutates.

DARPins are composed of protein structures that play an important role in protein interactions, and are smaller than monoclonal antibodies and lower production costs. In laboratory tests, DARPin’s two experimental drugs (ensovibep and MP0423) were “very effective” against mutant viruses found in the UK and South Africa, and other variants circulating around the world.

MP0423 enters the cell by targeting three proteins on the virus. Even if one of the proteins mutates, the drug can still attack the other two proteins and neutralize the virus. The researchers believe that these results, as well as the relatively small size and higher yield of DARPin molecules, indicate that ensovibep and MP0423 are better choices for monoclonal antibody cocktails. “

“Good” high-density lipoprotein (HDL) cholesterol levels are linked to lower COVID-19 risk

A study published in January on medRxiv stated that healthy “good” HDL cholesterol levels are associated with a low risk of severe COVID-19.

Researchers analyzed the records of 317,306 participants in the UK Biobank study, including 869 people who were hospitalized with COVID-19, and found that subjects with healthy HDL levels had a lower risk of contracting the new coronavirus, and infection Patients with the new coronavirus are less likely to be hospitalized. According to US guidelines, the healthy HDL level for men is at least 40mg/dL (1mmol/L), and for women it is at least 50mg/dL (1.3mmol/L).

The study found that after considering health behaviors, socioeconomic status and other factors, for every 0.2 mmol/L (about 8 mg/dL) increase in HDL cholesterol, the chance of hospitalization for COVID-19 decreased by 9%.

The author said that an early study of participants in the biobank found the same inverse relationship between HDL and patients hospitalized for other infectious diseases. The study did not prove that HDL itself can prevent COVID-19. , But the anti-inflammatory and immune properties of HDL can be used to explain the research results.

Viral load is the most important transmission factor

A report recently published in the journal “The Lancet Infectious Diseases” showed that the amount of virus in the nose and throat of COVID-19 patients is the most important factor in determining whether to infect others.

Researchers in Spain studied 282 patients and 753 recent close contacts. Its co-author, Michael Marks, London School of Hygiene and Tropical Medicine, said that although family members are most commonly infected, the viral load “is the decision to confirm the The most important factor in whether transmission occurs between contacts”, and cough or other symptoms do not seem to play an important role.

Even asymptomatic patients need to self-isolate, health authorities may need to consider more close contact tracing of individuals with higher viral loads. Another study by UK researchers that has not been peer-reviewed also reported similar results.

(source:internet, reference only)

Disclaimer of medicaltrend.org