Devel Cell: Scientists hope to clarify the fate of embryonic stem cells

Devel Cell: Scientists hope to clarify the fate of embryonic stem cells.  In a research report published in the international journal Developmental Cell, scientists from the University of California and other institutions elucidated the fate of embryonic stem cells through research; the researchers said that we all know that you must break a few eggs to breed chickens Stem cells, now they can successfully maintain embryonic stem cells (ESC, embryonic stem cells) in eggs. The relevant research results may provide scientists with new insights into the biological characteristics of stem cell pluripotency and evolutionary development.

Researcher Xi Chen said that choosing eggs from fertilization is the key to the success of our research, because fertilized eggs are easily obtained from the farm, and in the laboratory, it takes 5000 fertilized eggs to create a best way to maintain chicken embryonic stem cells. Good environment.

The researchers hope that the results of this article can also be used to study other poultry, such as quail or goose. Compared with embryonic stem cells in chickens, embryonic stem cells in quails have a shorter maturity time and small size, which may be more useful in the laboratory; and Further applications can be extended to food lines produced in development laboratories.

In addition, comparing embryonic stem cells in many different poultry species may help reveal their biological diversity and develop the potential to restore extinct or endangered species in the future.

At first, the researchers used a new gene editing technology called CRISPR to inactivate the gene called GSK3 in mouse embryonic stem cells. In this study, the researchers revealed that two forms of GSK3 are involved in the maintenance and differentiation of embryonic stem cells. Previous research results inspired researchers to pursue a more risky project, that is, to develop a method to maintain embryonic stem cells in chickens in an undifferentiated, self-renewing state. The International Stem Cell Research Society held in 2020 presented their research results on avian embryonic stem cells.

Finally, the researcher Chen pointed out that we want to develop embryonic stem cell lines in chickens for more in-depth research to clarify its characteristics and help understand the fate of embryonic stem cells.

(sourceinternet, reference only)

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