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A key breakthrough on artificial embryos research based on stem cells
A key breakthrough on artificial embryos research based on stem cells. The research team should now be able to better understand how these three types of stem cells interact to achieve embryonic development.
According to the latest British media, an international team of scientists has used mouse stem cells to cultivate a structure at a critical stage in the development of life, thereby taking a step towards creating artificial embryos.
According to a Reuters report, experts said that the results of this study indicate that it is possible to breed human embryos in a similar way in the future-which will allow scientists to use artificial embryos instead of real embryos to study the earliest stages of human development.
According to the report, the research team led by Professor Magdalena Zelnika-Gotz of the University of Cambridge in the United Kingdom had previously cultivated a simple structure similar to mouse embryos in a laboratory dish. That study used two kinds of stem cells and a three-dimensional scaffold on which stem cells can grow.
According to the report, in the new research results published in the British journal Nature Cell Biology, scientists used three kinds of stem cells to further develop this structure and realize a process called gastrulation, which is the beginning of embryonic cells. The necessary steps for self-organization into a correct structure to form an embryo.
Zelnika-Goetz said in a statement about the results of this study: “Our artificial embryos have experienced the most important events in life in a petri dish. They are now very close to real embryos.”
She said the research team should now be able to better understand how these three types of stem cells interact to achieve embryonic development. In addition, by experimentally changing the biological pathways of one of the cells, they will be able to see how this will affect the behavior of other types of cells.
Zelnika-Goetz said: “The rate of miscarriage in the early stages of embryonic development is high, but we don’t know much about this stage.”
She said: “Now that we have a way to simulate embryonic development in a petri dish, it will be possible to understand exactly what happens at this unusual stage of embryonic life and why this process sometimes fails.”
Christopher Galicher, a senior research scientist at the Francis Crick Institute in the United Kingdom, also believes that the results of this study bring hope. He was not directly involved in this research.
Galicher commented in an email: “Although (this study) did not use human stem cells, the idea that this technology could one day be used to study early human embryos is not far-fetched. These self-assembled human embryos will be research An invaluable tool for early human development.
(sourceinternet, reference only)