October 20, 2021

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Cancers: Eliminating senescent cells can improve cancer survival rate!

Cancers: Eliminating senescent cells can improve cancer survival rate!

 

Cancers: Eliminating senescent cells can improve cancer survival rate!  “Cancers” study uncovers the link between aging and cancer.  Fighting aging can also help us fight cancer.


If we talk about things that make humans powerless, aging must be one of them. The sun and the moon change, the sun rises and the moon sets, time is gone, and aging has become something that humans must face. Aging itself can also have a great impact on the body’s functions, including skin changes, wrinkles, and physical weakness.

But with aging, there is a more important problem, and that is health. With the increase of age, the incidence of various major diseases is also rising rapidly, especially after the age of 40, the incidence of various diseases will increase significantly. One of the most frightening is naturally cancer.

A long time ago, people were looking for the cause of cancer-the most fundamental cause of cancer is the mutation of the cell’s genes. This mutation allows the cell to get rid of its own life cycle and have an endless “lifespan”. It can begin to divide indefinitely, and after being further separated from the surveillance of immune cells, it is very likely to develop into cancer. And aging just promotes the 2 steps of cancer occurrence:

As age increases, the number of cell divisions increases, and at the same time being affected by external factors, the probability of cell division errors increases;

In the process of aging, the human body’s immune system will also degenerate, the “natural enemies” of cancer cells will decline, and the probability of cancer will greatly increase;

When the incidence of cancer cells increases, but the strength of immune cells that monitor and kill cancer cells decreases, it is inevitable that the incidence of cancer will increase.

Of course, aging has many aspects, one of which is that cells that only occupy a place and do not work-these are senescent cells, and we often call them “zombie cells”. They are indeed very similar to zombies: on the one hand, they It cannot be divided and does not perform many functions. On the other hand, it will release a lot of harmful substances and endanger human health. The appearance of senescent cells is also considered to be an important part of the aging process.

Since senescent cells are part of aging, can we fight aging-related diseases by eliminating senescent cells? The research published in “Cancers” tells us the answer!

 

Cancers: Eliminating senescent cells can improve cancer survival rate!

Image source: “Cancers” official website

 

In this study, the researchers included a total of 565 patients with stage 2 and stage 3 cervical cancer. A total of 19 serum proteins related to cervical cancer were extracted from the blood of these patients. Surprisingly, Among them, 10 kinds of tumor-specific proteins are closely related to aging.

 

Cancers: Eliminating senescent cells can improve cancer survival rate!

Image source: Reference 1

 

After analyzing the data of these patients, it is found that those patients with higher expression of senescent cell-related proteins will have a lower survival rate. Conversely, patients with low expression of aging-related proteins will have a higher survival rate.

 

Cancers: Eliminating senescent cells can improve cancer survival rate!

Image source: Reference 1

 

So can technology eliminate senescent cells and reduce their related secretion to increase the lifespan of patients? The research results confirmed this idea. After receiving treatment, when senescent cells decrease, the survival rate of cancer patients also increases!

 

Cancers: Eliminating senescent cells can improve cancer survival rate!

Image source: Reference 1

 

In many previous studies, we have mentioned that chronic inflammation can accelerate the occurrence of cancer. The substances secreted by senescent cells can easily cause local chronic inflammation. Therefore, when we kill senescent cells, it is possible to improve cancer patients’ Survival rate.

In this study, radiotherapy was used to kill senescent cells, and many studies have confirmed that immune cells in the human body can eliminate senescent cells, thereby promoting the “metabolism” of human cells. In addition, the immune cells themselves have been used in cancer treatment.

This is immune cell therapy. Perhaps in the future, we can also use immune cells to eliminate senescent cells, thereby reducing the risk of cancer and improving the survival rate of cancer patients.

 

 

 

 

 

 

 

(source:internet, reference only)


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