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Immune cells eliminate senescent cells and can extend the lifespan.
Immune cells eliminate senescent cells and can extend the lifespan. Immune cells eliminate senescent cells, not only can improve blood sugar, but also extend the life of terminally ill mice! The latest development of the “Cell” sub-journal.
One of the important reasons for the human body to get sick after aging. At present, aging is an inevitable process of human beings. It is accompanied by aging. In addition to changes in appearance, there is also a decline in health-aging is a great threat to health. Most diseases are closely related to aging, no matter it is Cardiovascular disease is still cancer, and its occurrence and development are inseparable from aging.
There are many reasons why aging has such a great impact on health. One of them is that as the human body ages, a lot of senescent cells will be produced. These senescent cells take up a place and do not work. They can also affect the living environment of the cells in the body and cause various inflammations. Of course, under normal circumstances, the body’s immune cells can eliminate senescent cells, but with aging, the human body’s immune system will continue to decline, resulting in the body’s inability to eliminate immune cells. This is one of the important reasons for the human body to get sick after aging.
So if we revitalize immune cells and clear senescent cells again, can we help humans overcome some of the diseases caused by aging? The answer is certainly feasible. The content published in the latest issue of the “Cell” sub-Journal “Med” brought us the achievements of immune cells to eliminate senescent cells, and successfully reversed the many harms caused by aging.
In a normal, young, and healthy population, the body’s own immune cells will look for and kill senescent cells, but in the case of aging, the immune cells seem to lose this function. So researchers began to look for immune cells that can kill senescent cells in the human body, and look for other activation methods to restore immune cells to combat effectiveness.
In the end, the researchers focused on a special type of immune cell, which is invariant Natural Killer T Cells (iNK cells). We are more familiar with NK cells, but iNK cells have very different characteristics from NK cells. iNK cells mainly have the following two characteristics, which makes them favored by researchers:
First of all, iNK cells have the same receptors, and these receptors are different from those of other immune cells, so iNK cells can work without activating other immune cells, so that there is no comparison to the overall immunity of the human body. Great influence
Secondly, iNK cells have natural negative feedback regulation in the human body. That is to say, the more active iNK cells are, the human body will naturally inhibit them. Therefore, when iNK cells function for a period of time, they will return to a dormant state under the body’s own regulation. Therefore, the long-term activation of iNK cells will not have a relatively large impact on the human body.
These two points make this special immune cell bear the burden of being awakened and killing senescent cells. In order to verify the effect of iNK on killing senescent cells, the researchers pretreated the mice. The results found that when iNK cells eliminated senescent cells in mice, mice that were obese due to diet had a significant improvement in their own blood sugar function-which means that eliminating senescent cells can help improve blood sugar regulation. This research can be verified in clinical studies, and may be a gospel for people who suffer from diabetes due to diet.
In order to further study the effect of iNK cells clearing senescent cells on human functions, the researchers turned their attention to another type of “terminal illness” that has a higher mortality rate than cancer-pulmonary fibrosis. The average survival time of patients with pulmonary fibrosis after diagnosis is only 2.8 years, and there is currently no optimal treatment.
Surprisingly, when the researchers used bleomycin to induce pulmonary fibrosis and caused the corresponding symptoms in the lungs of mice, and then used iNK cells to eliminate the cells associated with aging in the mouse model, the mice were damaged. The cells have been significantly reduced, and the life span of the mice has also been significantly extended! It can be said that it provides a potential hope for those patients who can only change their lungs after pulmonary fibrosis.
So for the human body, can iNK cells directly act on senescent cells? To put it simply, whether activated iNK cells will kill senescent cells (rather than normal cells) preferentially, so the researchers obtained peripheral blood cells from healthy people, separated and cultured them. In experiments, they found that iNK cells would Kill senescent cells first! This also laid a certain foundation for the further entry of this therapy into the clinic.
At 18 hours iNK cells destroy 100% of senescent cells
For aging, we still do not have a good way to contain it, but perhaps we can find the answer we want from the immune system. Similarly, as our understanding of the immune system becomes deeper and deeper, immunotherapy will not only be applied to cancer, but will also be applied to more health areas, including anti-aging, diabetes treatment, pulmonary fibrosis and other treatments.
(source:internet, reference only)