Why do breast cancer patients have multiple bone metastases?
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Why do breast cancer patients have multiple bone metastases?
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Why do breast cancer patients have multiple bone metastases? How to treat multiple bone metastases of breast cancer?
Cancer metastasis may be a situation that every cancer patient has to face. The disseminated tumor cells accompany the blood circulation and can reach almost any part of the body.
The most common ones are the bones, liver, lungs, brain, and distant lymph nodes.
For breast cancer, nearly 70% of metastases will appear on the bone; and almost all breast cancer subtypes are prone to bone metastasis.
As the most common type of cancer threatening women’s life and health, the multiple bone metastases of breast cancer cannot be ignored. So, what should be done if multiple bone metastases occur in breast cancer?
How do multiple bone metastases of breast cancer occur?
When the disseminated breast cancer cells break away from the original tumor lesions through the epithelial-mesenchymal transition process, they have the ambition and ability of “broad space and great accomplishment”.
They enter the bloodstream or lymphatic system, and ride a “hit ride” to get to wherever they want to go.
In this process, the secretion of cytokines from the bone marrow stromal may attract the attention of breast cancer cells, causing these cells to transfer to the bones and trigger a continuous vicious circle.
Of course, in the bones, these breast cancer cells that have completed metastasis will also remain dormant for a long time, thereby evading some therapeutic drugs.
Although the bone metastasis of breast cancer can theoretically appear in any bone position of the body, the most common clinically should be the long bones (humerus and femur) of the spine, pelvis, ribs, arms and legs.
How to treat multiple bone metastases of breast cancer?
For multiple bone metastases of breast cancer, the purpose of treatment is to relieve pain and other metastasis-related symptoms, maintain and improve mobility, strengthen bones, and slow the growth of cancer.
The specific treatment method depends on the scope and location of bone metastases, but also needs to consider the treatment methods the patient has received in the past, whether they have experienced menopause, and the overall health status.
At present, the most common treatment for multiple bone metastases of breast cancer is systemic therapy, which means the treatment of primary and metastatic tumor lesions at the same time, including chemotherapy, hormone therapy, targeted therapy and bone enhancement therapy.
In addition, multiple bone metastases of breast cancer can also be treated with local treatments such as surgery and radiotherapy.
The treatment of bone metastasis can prolong survival time and relieve symptoms to a certain extent. Generally speaking, bone metastasis can be managed stably for a long time. In the case of only bone metastases, if appropriate treatment is given, the risk of death can be reduced by up to 44%.
For multiple bone metastases of breast cancer, in fact, a better treatment is prevention. Studies have shown that bisphosphonates can reduce the incidence of bone metastases; in addition, it is also a good choice to have bone scan-related examinations every year; at the same time, we can also monitor the level of indicators in the body that can reflect bone metastasis. Even if there is bone metastasis, please don’t panic. Actively seek and accept regular treatment. Breast cancer bone metastasis is not terrible.
Why do breast cancer patients have multiple bone metastases?
(source:internet, reference only)
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