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Cell Reports Medicine: Meconium can help predict the risk of allergies
Cell Reports Medicine: Meconium can help predict the risk of allergies. Meconium is the feces formed by the baby in the mother’s body.
More than 20 weeks of pregnancy, meconium is present in the intestinal tract of the fetus. Meconium is the earliest intestinal secretion product of newborns, and it is viscous. Meconium is not only a rich source of metabolites reflecting the effects of the perinatal period, but also contains the starting material of the initial microbiota.
Image source: Cell Reports Medicine
Recently, a study published in Cell Reports Medicine showed that meconium is like a time capsule, revealing a lot of health information about newborns. The fewer types of microorganisms contained in meconium, the greater the risk of allergies in babies after one year.
In this study, researchers analyzed meconium samples from 100 infants in the CHILD cohort study, early samples (median age of 3 months) and late samples (median age of 1 year) to explore early infant microbes The key link between herd and immune development.
Studies have found that the development of a healthy immune system and microbiota may actually begin before the baby is born, and indicates that the microbiota exposed to the baby in the womb plays a fundamental role in future health.
Meconium metabolome affects the composition of the microbiota in early life.
Researchers identified the top 15 bacterial taxa and ranked them according to the importance of the microbiota, and then found that the relative abundance of these key taxa exhibited significant dynamic fluctuations early in life. Although the relative abundance of Enterobacteriaceae and Staphylococcus decreased over time, the abundance of most groups increased.
The microbial diversity of meconium is related to atopic protection after 1 year.
The researchers also found that the reduction of certain molecules is related to changes in key bacterial populations. These bacterial groups play a key role in the development and maturation of the huge gut microbial ecosystem, such as infant allergic reactions. Many children with allergic allergies have a life-long burden, and there is currently almost no treatment. Therefore, identifying high-risk infants early in life may have a positive impact on the prevention of allergic diseases.
“These metabolic characteristics, coupled with early microbiota and clinical factors, predict with high accuracy (76%), and predict whether babies will develop allergies more reliably than ever before,” the researchers said.
(source:internet, reference only)