October 18, 2021

Medical Trend

Medical News and Medical Resources

How high-fat diets or obesity due to genetic factors can lead to hair loss?

How high-fat diets or obesity due to genetic factors can lead to hair loss?



How high-fat diets or obesity due to genetic factors can lead to hair loss?

With economic development and improvement of living standards, obesity has become a major public health problem worldwide. According to statistics from the World Health Organization (WHO), nearly 2 billion people are overweight or obese in the world. From 1975 to 2016, the global obesity rate has nearly tripled. Every year, overweight or obesity causes 2.8 million deaths.

In fact, obesity not only causes inconvenience in life and decreased exercise capacity, obesity is also a disease. Obese people are more likely to suffer from metabolic diseases and cardiovascular and cerebrovascular diseases. In addition, many studies have shown that obesity and more than a dozen types of cancer have an increased risk and prognosis. And the survival rate is reduced.

However, we do not yet fully understand how the body organs deteriorate and lose function due to chronic obesity.

Recently, researchers from Tokyo Medical and Dental University published a research paper titled: Obesity accelerates hair thinning by stem cell-centric converging mechanisms in the top international academic journal Nature.

The study used mouse model experiments to study how high-fat diets or obesity due to genetic factors can lead to hair loss. Test results show that high-fat diet or obesity caused by genetic factors can cause hair follicle stem cells (HFSC) to deplete by inducing inflammatory signals, blocking hair follicle regeneration, leading to loss of hair follicles, and ultimately leading to thinning and hair loss.

How high-fat diets or obesity due to genetic factors can lead to hair loss?

Under normal circumstances, hair follicle stem cells (HFSC) will renew themselves in each hair follicle cycle, which is also part of the process by which our hair can continue to grow back.

However, with age, hair follicle stem cells gradually cannot replenish themselves, resulting in a gradual decrease in hair follicle stem cells, leading to thinning of the hair.

Although overweight people have a higher risk of androgenetic alopecia, whether obesity will accelerate hair loss, its mechanism and molecular mechanism are largely unknown.

Experimental results show that feeding mice with a high-fat diet will consume their hair follicle stem cells, thereby accelerating hair thinning, especially in elderly mice. The research team further compared the gene expression of hair follicle stem cells between mice fed a high-fat diet and mice fed a standard diet, and tracked the fate of these hair follicle stem cells.

How high-fat diets or obesity due to genetic factors can lead to hair loss?

It was found that the hair follicle stem cells in obese mice fed with a high-fat diet changed their fate and turned into skin surface keratinocytes or sebum secreting cells. These mice showed faster hair loss, smaller hair follicles, and hair follicles. Consumption of stem cells.

How high-fat diets or obesity due to genetic factors can lead to hair loss?

The study’s corresponding author Emi K. Nishimura said that even after only four consecutive days of high-fat diet, hair follicle stem cells showed signs of increased oxidative stress and epidermal differentiation. Gene expression in hair follicle stem cells of mice fed a high-fat diet indicated that inflammatory cytokine signaling in hair follicle stem cells was activated, which significantly inhibited the Sonic Hedgehog signaling pathway, which plays a key role in hair follicle regeneration.

The research team further stated that this also reminds us that activating the Sonic Hedgehog signaling pathway can save the depletion of hair follicle stem cells and prevent hair loss caused by a high-fat diet.

Overall, this research provides interesting new insights into specific cell fate changes and tissue dysfunction that may occur after a high-fat diet or genetic obesity, and may open up future prevention and treatment of hair loss and understanding of obesity-related diseases. door.

Paper link:
https://www.nature.com/articles/s41586-021-03624-x

How high-fat diets or obesity due to genetic factors can lead to hair loss?

(source:internet, reference only)


Disclaimer of medicaltrend.org