Is Dietary Supplement Glucosamine related to Colorectal Cancer ( CRC)?
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Is Dietary Supplement Glucosamine related to Colorectal Cancer ( CRC)?
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Is Dietary Supplement Glucosamine related to Colorectal Cancer ( CRC)?
Cancer Epidemiol Biomarkers Prev 丨 Glucosamine use and risk of colorectal cancer: results from the UK Biobank.
Background:
Use of the dietary supplement glucosamine is associated with a reduced risk of colorectal cancer (CRC); however, it is unclear whether this association varies by screening status, timing, and other factors.
Methods:
We therefore assessed these questions in the UK Biobank. Multivariate-adjusted hazard ratios (HRs) and 95% confidence intervals (95% CI) were estimated using Cox proportional hazards regression.
RESULTS:
No association was observed between glucosamine use and overall CRC risk (HR = 0.94; 95% CI: 0.85-1.04). However, the association varied by screening status (p-interaction: 0.05), with an inverse association observed only in unscreened individuals (HR = 0.86; 95% CI: 0.76-0.98).
When stratified by time of study, an inverse association was observed at early follow-up in the early entry cohort (2006-2008, HR = 0.80; 95% CI: 0.67-0.95).
No heterogeneity was observed with respect to age, sex, body mass index, smoking status, or use of NSAIDs.
Conclusions:
While there was no association between glucosamine use and overall CRC, the inverse association between individuals who had never been screened mirrored our observations in a previous exploratory analysis of a US cohort.
The National Health Service Bowel Cancer Screening Programme was launched in the UK in 2006 and was more widely implemented in the UK by 2009.
Consistent with this, we observed that the inverse association was limited to early follow-up in patients surveyed in 2006-2008, before widespread implementation of screening.
Impact: These data suggest that unscreened individuals may benefit from glucosamine use; however, further research is needed to confirm the interaction of screening and timing.
Reference:
Kantor ED, O’Connell K, Liang PS, et al. Glucosamine Use and Risk of Colorectal Cancer: Results from UK Biobank. Cancer Epidemiol Biomarkers Prev. 2022 Jan 13;cebp.1171.2021. doi: 10.1158/1055-9965.EPI- 21-1171.
Is Dietary Supplement Glucosamine related to Colorectal Cancer ( CRC)?
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