June 14, 2024

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Key risk factors of Colorectal Cancer : Red meat Alcohol and Aspirin…

The incidence of colorectal cancer has been younger! Large-scale research to identify key risk factors: red meat, alcohol and aspirin…


Key risk factors of Colorectal Cancer : Red meat Alcohol and Aspirin… 

Many people are accustomed to linking aging to worsening health and increased risk of disease. However, when it comes to cancer, the situation is not so simple. For example, colorectal cancer.


Colorectal cancer (colorectal cancer, CRC) is a general term for cancers that initially develop in the tissues of the colon or rectum. It is one of the most common malignant tumors worldwide.


According to the latest global data released by the International Agency for Research on Cancer (IARC) of the World Health Organization in 2020, colorectal cancer is the third most common cancer after breast and lung cancer, accounting for up to 9.4% of patients. Among them, colorectal cancer patients in China Accounted for 31% of the world. 


Not only that, in many other countries, the incidence of early-onset colorectal cancer (people younger than 50 years old) has been increasing year after year. Therefore, it is imperative to clarify the traditional risk factors that lead to the early stage of this cancer.


In a new study published in “JNCI Cancer Spectrum”, a large international research team led by New York University in the United States conducted the first large-scale study of non-genetic risk factors for early-onset colorectal cancer and found that red meat intake is higher.

Many factors, such as low level of education and excessive drinking, are related to the increase in the incidence of colorectal cancer among people under the age of 50. This research provides a basis for the targeted identification of high-risk groups.


The increase in patients with early-onset colorectal cancer is worrying researchers, because these cases are often worse than those diagnosed in the elderly.

Therefore, some countries recommends that people with a higher risk of colorectal cancer undergo regular screening from the age of 40. The American Cancer Society has also called for screening to begin at the age of 45.


Previous studies have outlined the potential risk factors for early colorectal cancer, including low intake of processed meat, vegetables and citrus fruits, high body mass index (BMI), sedentary lifestyle, Drinking a lot of alcohol, smoking, not taking aspirin regularly, diabetes, etc.


Key risk factors of Colorectal Cancer : Red meat Alcohol and Aspirin...


However, scientists have not yet conducted a comprehensive, large-scale assessment to compare these risk factors with the risk of late-onset colorectal cancer and assess whether the risk of early-onset is related to a specific type of colorectal cancer.


In this study, the researchers analyzed three large studies from the Colon Cancer Family Registry, Colorectal Interdisciplinary Research, and Colorectal Cancer Genetics and Epidemiology, which involved 67168 colorectal cancer cases and 710377 control groups , Thus confirming the epidemiological study investigating detailed risk factors.


Using data from 13 population-based studies, researchers investigated 3767 colorectal cancer cases and 4,049 control cases in people under 50 years old; 23,437 colorectal cancer cases and 35311 control cases were investigated in people over 50 years old. 


The reference ages of early-onset colorectal cancer cases and control cases were similar, 45.0 years old and 44.7 years old, respectively; the distribution between genders was roughly the same. In cases under 50 years of age, the rectum was the first disease site (39.8%), followed by the distal colon (32.3%) and the proximal colon (27.9%).


The results of this study prove that some of the non-genetic factors known to be involved in late-onset colorectal cancer are also related to early-onset diseases.


By assessing the risk of early-onset colorectal cancer by cancer site, researchers found that non-steroidal anti-inflammatory drugs (aspirin) were not taken regularly, higher red meat intake, lower dietary fiber, folic acid and calcium intake , Higher alcohol intake and lower education are all related to higher risk of early-onset diseases of the rectum and colon.


The researchers further compared the correlation factors between the colon and rectum and found that compared with colon cancer, lower total dietary fiber intake is more correlated with rectal cancer.

Other risk factors also tend to increase the risk of rectal cancer, including not taking non-steroidal anti-inflammatory drugs (aspirin) regularly and reducing folic acid intake.


The corresponding author of the study, Professor Richard Hayes of the Department of Population Health and Department of Epidemiology, New York University School of Medicine, said: “This is the first large-scale study of non-genetic risk factors for early-onset colorectal cancer. High-risk groups provide an initial basis, which is essential to alleviate the growing burden of this disease.”




Key risk factors of Colorectal Cancer : Red meat Alcohol and Aspirin…

(source:internet, reference only)

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