Male contraceptives have a new breakthrough and no obvious side effects
- Why are vegetarians more likely to suffer from depression than meat eaters?
- Small wireless device implanted between skin and skull helps kill cancer cells
- Will the mRNA vaccine that can cure cancer come out near soon?
- Allogeneic T-cell therapy set for landmark first approval
- Boston University denies that the new COVID strain they made has 80% fatality rate
- A new generation of virus-free CAR-T cell therapy
Male contraceptives have a new breakthrough and no obvious side effects
- First human trial of HIV gene therapy: A one-time cure will be achieved if successful!
- New breakthrough in CAR-T cell therapy: Lupus erythematosus patients achieved treatment-free remission for up to 17 months
- How long can the patient live after heart stent surgery?
- First time: Systemic multi-organ recovery after death
- Where do the bacteria in the human gut come from?
Male contraceptives have a new breakthrough and no obvious side effects
Currently, male contraceptive methods are limited to vasectomy and condoms, although researchers hope to provide more options in the future.
A new study shows two experimental male birth control pills successfully lowered testosterone.
Presented at the Endocrine Society’s annual meeting (ENDO) in Atlanta, Georgia, USA, the study showed that two experimental male contraceptives appear to successfully lower testosterone without causing unacceptable side effects.
The two drugs, called DMAU and 11-MNTDC, are classified as progestin androgen. These drugs lower testosterone, which reduces sperm count.
Lowering testosterone levels often has unpleasant side effects. And most of the men in the trial were willing to continue taking the medication, indicating that the side effects were acceptable.
Project leader Tamar Jacobsohn said: “Male contraceptive options are currently limited to vasectomy and condoms and are therefore extremely limited compared to female contraception.
The development of an effective, reversible male contraceptive Contraceptive methods will improve reproductive choices for men and women, have a major public health impact by reducing unwanted pregnancies, and enable men to play an increasingly active role in family planning.”
Jacobson is the Principal Investigator of the Contraceptive Development Program at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).
The study included two Phase 1 clinical trials involving a total of 96 healthy male participants. Over a 28-day period, the men in each trial were given two to four oral pills containing the active drug or a placebo.
Testosterone levels were lower than normal after taking the active drug for 7 days. Testosterone levels in the men taking the placebo remained within the normal range.
The study found that 75% of men taking the active drug said they would be willing to use it in the future, compared to 46.4% of men taking a placebo.
Men who took four tablets (400 mg) per day had lower testosterone levels than men who took two 200 mg tablets.
There were no significant differences between the two active treatment groups in their satisfaction with the medication or their willingness to use or recommend it to others in the future.
Male contraceptives have a new breakthrough and no obvious side effects
(source:internet, reference only)
Disclaimer of medicaltrend.org
