September 28, 2022

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Male contraceptives have a new breakthrough and no obvious side effects

Male contraceptives have a new breakthrough and no obvious side effects



 

Male contraceptives have a new breakthrough and no obvious side effects

Currently, male contraceptive methods are limited to vasectomy and condoms, although researchers hope to provide more options in the future.

A new study shows two experimental male birth control pills successfully lowered testosterone. 

Presented at the Endocrine Society’s annual meeting (ENDO) in Atlanta, Georgia, USA, the study showed that two experimental male contraceptives appear to successfully lower testosterone without causing unacceptable side effects.

 

Male contraceptives have a new breakthrough and no obvious side effects

 

 

The two drugs, called DMAU and 11-MNTDC, are classified as progestin androgen. These drugs lower testosterone, which reduces sperm count.

Lowering testosterone levels often has unpleasant side effects. And most of the men in the trial were willing to continue taking the medication, indicating that the side effects were acceptable.

 

Project leader Tamar Jacobsohn said: “Male contraceptive options are currently limited to vasectomy and condoms and are therefore extremely limited compared to female contraception.

The development of an effective, reversible male contraceptive Contraceptive methods will improve reproductive choices for men and women, have a major public health impact by reducing unwanted pregnancies, and enable men to play an increasingly active role in family planning.”

 

Jacobson is the Principal Investigator of the Contraceptive Development Program at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).

 

The study included two Phase 1 clinical trials involving a total of 96 healthy male participants. Over a 28-day period, the men in each trial were given two to four oral pills containing the active drug or a placebo.

Testosterone levels were lower than normal after taking the active drug for 7 days. Testosterone levels in the men taking the placebo remained within the normal range.

 

The study found that 75% of men taking the active drug said they would be willing to use it in the future, compared to 46.4% of men taking a placebo.

Men who took four tablets (400 mg) per day had lower testosterone levels than men who took two 200 mg tablets.

There were no significant differences between the two active treatment groups in their satisfaction with the medication or their willingness to use or recommend it to others in the future.

 

 

Male contraceptives have a new breakthrough and no obvious side effects

(source:internet, reference only)


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