May 30, 2024

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 What are benefits when children take Vitamin D3 before 2 years old?

 What are benefits when children take Vitamin D3 before 2 years old?


What are benefits when children take Vitamin D3 before 2 years old?


It has to be said that there are too many health products and nutritional supplements under various names.

Parental folic acid supplementation reduces the risk of birth defects in offspring, vitamin D supplementation reduces the risk of dementia, and supplementation with fish and marine sources of omega-3 PUFAs is associated with a reduced risk of cancer…


However, one thing that almost all supplements also have in common is that they must be within the recommended dosage. Oversupplementation may not only bring no benefit, but may increase dose-related risks.


For children, especially newborns, vitamin D levels are related to brain and bone development, and most newborns face the risk of low vitamin D levels. China and most countries recommend that newborns start vitamin D supplementation within a few days after birth. It is 400IU/day .


Children are so fragile, if they make up too much, something will happen. Probably all parents think so.


However, a recent study published in JAMA Network Open proves that vitamin D3 supplementation, much more than the recommended dose, is also possible .


Samuel Sandboge of the University of Tampere in Finland and his research team conducted a secondary analysis of a randomized clinical trial involving 346 children and found that supplementing high doses of vitamin D3 (1200IU) before the age of 2 was associated with internalization at the age of 6-8 associated with a lower risk of problems .


What are benefits when children take Vitamin D3 before 2 years old?



Lower vitamin D levels in children have been linked to increased depression, internalizing problems, and increased externalizing problems.

Common internalizing problems include anxiety, depression, low self-esteem, self-doubt, guilt, self-denial, etc., and are usually related to emotion regulation, self-knowledge, self-evaluation and coping mechanisms; externalizing problems, as opposed to internalizing problems, involve Direct transfer of difficulties, conflicts, or emotions to the external world, manifested in behavior as aggression, resistance, impulsive behavior, etc.


In 2021, Samuel Sandboge and his research team conducted a double-blind, interventional randomized controlled trial (VIDI study) on the effects of supplementing standard doses (400IU) and high doses (1200IU) of vitamin D3 in children early in life (<2 years old).

The results showed that high-dose vitamin D3 supplementation did not have a positive effect on neurodevelopment in children under 2 years of age .


However, considering that behavioral and mental problems may not be fully manifested in children’s early life activities, and the earliest peak age of onset of anxiety and fear-related diseases is 5.5 years old, the researchers believe that it is necessary to extend the follow-up time based on previous studies, Extend to 6-8 years old.


The researchers conducted follow-up long-term follow-up and secondary analysis of 346 children in the VIDI study. 169 children (34.6%) received vitamin D3 supplements at a dose of 400IU, and 177 children (36.4%) received supplements at a dose of 1200IU. Children’s psychiatric status was assessed using the Child Behavior Checklist (CBCL) (composite score of internalizing, externalizing, and total problems).


What are benefits when children take Vitamin D3 before 2 years old?

baseline characteristics


When children were 1 or 2 years old, the 25(OH)D levels of children in the 1200IU group were significantly higher than those in the 400IU group.

Among children aged 6-8 years, 20 children (11.8%) in the 400IU group had clinically significant internalization problems, and 10 children (5.6%) in the 1200IU group had clinically significant internalization problems .

A 60% reduction in the risk of clinically significant internalization problems was associated . The results remained significant after adjusting for factors such as gender, season of birth, and parental status.


Additionally, 16 children in each group had externalizing problems (9.5% vs 9.0%, p=0.83).


Children with higher 25(OH)D levels at 1 and 2 years were associated with a lower risk of developing clinically significant internalization problems (1 year: OR 0.93; 2 years: OR 0.95).

After adjusting for related factors, the effect of 25(OH)D level at 1 year old on internalizing problem scores weakened, but the effect on the occurrence of clinically meaningful internalizing problems remained (OR 0.94). In contrast, children’s 25(OH)D levels had no effect on externalizing or total problems.


The researchers also performed subgroup analyzes according to maternal 25(OH)D levels. Results of the analysis showed that children in the 1200 IU group with maternal 25(OH)D levels ≥30 ng/mL were associated with clinically significant internalization problems compared to children in the 400 IU group with maternal 25(OH ) D levels <30 ng / mL 79% reduction in risk associated with(adjusted OR 0.21 ).


When maternal 25(OH)D levels were below 30ng/mL, children in the 400IU group scored higher on internalizing problems compared with children in the 1200IU group (adjusted mean difference, 0.49), and children in the 1200IU group had 25(OH)D When ≥30ng/mL, the difference was more significant (adjusted mean difference 0.37).

But when the mother’s 25(OH)D level was ≥30ng/mL, there was no significant difference between the 400IU group and the 1200IU group .


Overall, the study found that supplementing children up to 2 years of age with higher than recommended doses of vitamin D3 may be associated with a lower risk of internalization problems during the 6-8 year period. However, the results of this study need to be interpreted in the context of children’s health and development, and safety needs to be assessed.







[1] Sandboge S, Räikkönen K, Lahti-Pulkkinen M, et al. Effect of Vitamin D3 Supplementation in the First 2 Years of Life on Psychiatric Symptoms at Ages 6 to 8 Years: A Randomized Clinical Trial[J]. JAMA Network Open , 2023, 6(5): e2314319-e2314319.

[2] Tuovinen S, Räikkönen K, Holmlund-Suila E, et al. Effect of high-dose vs standard-dose vitamin D supplementation on neurodevelopment of healthy term infants: A randomized clinical trial[J]. JAMA Network Open, 2021, 4(9): e2124493-e2124493.

What are benefits when children take Vitamin D3 before 2 years old?

(source:internet, reference only)

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Important Note: The information provided is for informational purposes only and should not be considered as medical advice.