June 22, 2024

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Researchers create Trojan horse with mRNA to induce cancer to produce toxins to kill itself

Researchers create Trojan horse with mRNA to induce cancer to produce toxins to kill itself



 

Researchers create Trojan horse with mRNA to induce cancer to produce toxins to kill itself.

Scientists have developed and tested a new potential cancer treatment method that works similarly to COVID-19 vaccines.

The technique involves providing mRNA molecules to cancer cells and inducing them to produce toxic proteins that can kill tumors.

All living cells contain ribosomes, which can be seen as tiny factories for protein production. Specifically, the proteins they manufacture depend on the “blueprints” they receive, which come from messenger RNA (mRNA) molecules.

 

 

Over the past few decades, scientists have discovered that they can hijack this mechanism to make beneficial proteins on demand.

This mRNA technology has been greatly accelerated by the COVID-19 pandemic, as the vaccines developed by BioNTech and Moderna work by tricking our cells into producing a virus-like spike protein, triggering an immune response that trains our bodies to fight subsequent infections.

 

Since then, scientists have turned their attention to cancer, trying to use mRNA to produce tumor-mimicking proteins that help kickstart an immune response against cancer.

This could be a particularly promising path when paired with other treatments such as immunotherapy.

 

But in new research, scientists at Tel Aviv University in Israel have created an mRNA cancer treatment that works in a different way.

The mRNA molecules are encoded to produce a toxin made by the bacteria, which are then packaged into lipid nanoparticles and injected into the tumor. This causes the cells to start producing toxins, effectively poisoning themselves. This could be a safer option than chemotherapy, which also harms healthy cells, the team said.

 

Researchers create Trojan horse with mRNA to induce cancer to produce toxins to kill itself

 

 

Professor Dan Pell, co-leader of the study, said: “By a simple injection into the tumor bed, we can induce cancer cells to ‘suicide’ without damaging healthy cells. Furthermore, cancer cells cannot respond to cancer as often happens in chemotherapy. Our technique creates resistance — because we can always use a different natural toxin.”

 

In tests on mice with melanoma, 44% to 60% of cancer cells were destroyed after a single injection. Tumor growth was slowed, and the survival rate of the mice was significantly higher than that of control mice. No adverse effects were seen in these animals.

 

While the idea sounds appealing, it’s important to note that this is the early stage of research. There’s no guarantee the findings will carry over to humans, and larger animal trials are needed first.

The study was published in the journal Theranostics.

 

 

 

 

 

Researchers create Trojan horse with mRNA to induce cancer to produce toxins to kill itself

(source:internet, reference only)


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