May 19, 2024

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Clinical results of hallucinogenic mushrooms for anorexia nervosa published

Clinical results of hallucinogenic mushrooms for anorexia nervosa published


Nature Medicine: Clinical results of hallucinogenic mushrooms for anorexia nervosa published.

When it comes to mushrooms , I believe most people will immediately think of delicious food.

However, not all mushrooms are non-toxic and edible, and there are not a few people admitted to hospital every year due to eating poisonous wild mushrooms by mistake.

Not only that, some mushrooms also contain hallucinogenic toxins, which make people have colorful and dreamy hallucinations.

The psilocybin (also called psilocybin) they contain can make people have visual and visual hallucinations within a few hours after ingestion. It is a neurotoxin with neuropsychiatric effects.


A number of recent clinical trials have shown that psilocybin can effectively treat depression , which may be because psilocybin can rebuild and enhance the functional network connection between brain neurons.


Anorexia nervosa (ANorexia Nervosa, AN)is a difficult-to-treat psychiatric disorder characterized by excessive and inappropriate concern, fear, and stress about food, weight and shape, and eating.

There are currently no recognized treatments for anorexia nervosa in adults that reverse core symptoms, nor are there any approved pharmacological interventions.


Psilocybin has been shown in clinical trials to be promising in the treatment of mental disorders such as depression, and is associated with affect the symptoms ofanorexia nervosa .


On July 24, 2023, researchers from the University of California, San Diego published a research paper entitled: Psilocybin therapy for females with anorexia nervosa: a phase 1, open-label feasibility study in the journal Nature Medicine .


The paper reported a small-scale phase 1 clinical trial. The results of the trial showed that injection of a single dose of psilocybin in addition to psychological counseling is a safe and acceptable treatment for anorexia nervosa,  and may reduce the eating disorder behavior of some patients. This lays the foundation for further evaluation of psilocybin as a new treatment.





The research team let 10 adult female anorexic patients between the ages of 18 and 40 receive a single dose of 25 mg of COMP360 psilocybin (a synthetic form of psilocybin developed by COMPASS Pathways) in addition to psychological counseling, and followed up for 3 months after the single dose injection to evaluate the safety, drug resistance and exploratory efficacy of this therapy .


The research team pointed out that the subjects reported no serious adverse reactions, and the immediate effects of this psilocybin therapy were well tolerated.

Qualitative responses from patient self-reports showed that 90% considered psilocybin therapy to be meaningful and positive and endorsed further treatment where possible.

In addition, the research team pointed out that at the three-month follow-up, the eating disorder scores of the four subjects decreased significantly, achieving remission of eating disorder psychopathology.

However, they stress that these are preliminary results and further research is still needed.




The team noted that these results were from a small sample size and did not include a control group, so they should be interpreted with caution.

They concluded that while they found psilocybin therapy to be a safe and acceptable treatment, future randomized controlled trials are needed to confirm the results.





Paper link :

Clinical results of hallucinogenic mushrooms for anorexia nervosa published

(source:internet, reference only)

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