May 20, 2024

Medical Trend

Medical News and Medical Resources

High intake of aspartame increases the risk of type 2 diabetes 63%!

High intake of aspartame increases the risk of type 2 diabetes 63%!



 

High intake of aspartame increases the risk of type 2 diabetes 63%!

The 9-year follow-up data of more than 100,000 people showed that high intake of aspartame was associated with a 63% increase in the risk of type 2 diabetes!

There is one thing to say, although the WHO lists aspartame as a possible carcinogen of level 2B, but 2B is actually an uncertain level of carcinogenic risk to humans.

Considering that many things listed as Class 1 carcinogens still appear in normal life (such as alcohol), it seems a bit ironic to say that aspartame is carcinogenic.

 

Compared with carcinogenicity,  we should pay more attention to a non-sugar sweetener guideline issued by the WHO earlier.

The guideline recommends not to use any sugar substitutes to control weight , because based on the existing evidence, the use of sugar substitutes is not Long-term use of sugar substitutes is more likely to bring about potential adverse effects such as type 2 diabetes, cardiovascular disease, and increased risk of death, regardless of the long-term benefits of fat loss in adults or children .

 

Recently, the journal “Diabetes Care” published the data of a large cohort study, which is a strong support for the above conclusions.

Based on the 9.1-year follow-up results of 105,588 participants in the NutriNet-Santé study, compared with non-consumers, higher consumers of sugar substitutes (higher intake of 16.4mg/d for men and 18.5mg/d for women) suffered from Type 2 diabetes risk was 69 percent higher .

Positive associations between intake and risk were also observed for individual sugar substitutes, with aspartame, acesulfame K, and sucralose associated with 63%, 70%, and 34% increased risk of type 2 diabetes, respectively .

 

A can of sugar substitute drink with a standard size of 330ml contains about 130mg of sugar substitute . This reminds us again that sugar substitutes are not painless substitutes for sugar.

 

High intake of aspartame increases the risk of type 2 diabetes 63%!High intake of aspartame increases the risk of type 2 diabetes 63%!
Thesis title map

 

The main subjects of this study are aspartame, acesulfame-K and sucralose, three traditional old sugar substitutes. It is the first time to quantify the intake of artificial sweeteners from the daily diet.

 

Of the 105,588 participants involved in this cohort, 79.2% were women, with a median age of 42.5±14.6 years, of which 37.1% were defined as sugar substitute consumers, with a median intake of 42.3±72.1mg/d, which was approximately equal to Drink 100ml sugar substitute drink every day .

Consumers of aspartame, acesulfame-K and sucralose accounted for 28.1%, 34.5% and 13.9% of the research population respectively.

 

Among the total intake of artificial sweeteners, aspartame was the best, accounting for 58%, acesulfame K accounted for 29.1%, and sucralose accounted for 10.1%.

Sugar substitute drinks, added sugar on the table, and added sugar dairy products are the main sources of intake of sugar substitutes.

 

High intake of aspartame increases the risk of type 2 diabetes 63%!


The median follow-up of the cohort was 9.13 years, for a total follow-up of 946,650 person-years. After the study began, 972 participants were diagnosed with type 2 diabetes, with a mean age of 59.2 ± 11.4 years.

 

Sugar substitute consumers had a 69 percent higher risk of type 2 diabetes compared with nonusers. Aspartame, acesulfame K, and sucralose were associated with 63%, 70%, and 34% increased risk of type 2 diabetes, respectively.

 

High intake of aspartame increases the risk of type 2 diabetes 63%!


The trends in the conclusions remained unchanged after excluding patients diagnosed in the first 6 years of follow-up or participants with cardiometabolic risk factors for type 2 diabetes.

 

Obviously, if it is to avoid sugar, sugar substitutes are not a good substitute.

 

In terms of mechanism, many previous studies have provided us with answers. Studies have shown that the intake of sugar substitute beverages can lead to glucose metabolism disorders, accompanied by decreased β-cell sensitivity and insulin secretion; sugar substitutes may promote lipogenesis and reduce fat breakdown; sugar substitutes can interfere with intestinal bacteria, resulting in elevated blood sugar and Elevated levels of metabolites associated with type 2 diabetes.

 

Finally, a little personal opinion. Sweetness is no longer a wonderful experience that is difficult to obtain in modern society, or it is better to say that sweetness is too much to make people feel a little bored.

Instead of using sugar substitutes to deceive the body to reduce the “guilty feeling” of eating sweets, it is better to plan the sugar intake reasonably, cherish and enjoy some real sweetness, what do you think?

 

 

 

 

 

 

 

References:

[1] https://diabetesjournals.org/care/article/doi/10.2337/dc23-0206/153434/Artificial-Sweeteners-and-Risk-of-Type-2-Diabetes

High intake of aspartame increases the risk of type 2 diabetes 63%!

(source:internet, reference only)


Disclaimer of medicaltrend.org


Important Note: The information provided is for informational purposes only and should not be considered as medical advice.