Some case studies of childhood hepatitis of unknown etiology: or related to COVID-19
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Some case studies of childhood hepatitis of unknown etiology: or related to COVID-19.
Israeli researchers recently published a report saying that a study of some children with hepatitis cases of unknown etiology showed that infection with the new coronavirus may cause related symptoms.
Researchers at Israel’s Schneider Children’s Medical Center and other institutions analyzed the cases of five children hospitalized with liver damage. The patients, who were asymptomatic or mildly infected with the new virus before developing liver problems, ranged in age from 3 months to 13 years.
The researchers believe that one possibility of causing liver damage is that the new coronavirus directly causes damage by binding to the receptor “angiotensin-converting enzyme 2” (ACE2) on human cells.
Another possibility is that the immune system under- or over-reacts to SARS-CoV-2 infection, which can lead to a multisystem inflammatory syndrome in children, which can lead to liver damage.
Adenovirus was previously considered the “biggest suspect” in a global investigation of childhood hepatitis of unknown etiology.
Studies have shown that some of the above-mentioned cases tested positive for adenovirus, while others were negative. The researchers analyzed liver samples from these cases and found no antigens that pointed to the adenovirus or signs of adenovirus-induced hepatitis.
The researchers therefore believe that adenoviruses are not necessarily the main cause of disease, although the virus often causes severe hepatitis in immunocompromised people.
At present, there is no clear conclusion in the medical community about the reasons for the occurrence of childhood hepatitis cases of unknown etiology in many places around the world.
The research has been published in “Journal of Pediatric Gastroenterology and Nutrition“.
(source:internet, reference only)
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