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What causes the occurrence of esophageal cancer?
What causes the occurrence of esophageal cancer? Esophageal cancer is one of several common malignant tumors. Esophageal cancer has different pathological types such as adenocarcinoma and squamous cell carcinoma.
Adenocarcinoma is mainly in the lower esophagus and the junction of the esophagus and stomach, and squamous cell carcinoma is mainly in the upper and middle esophagus. Some people will certainly ask, if a certain country or a certain region has a high incidence of certain cancers, of course, there are certain risk factors that are more likely to cause this high incidence of cancer in this country or this region.
High-risk factors that may be related to esophageal cancer:
1. Nitrosamine compounds, mycotoxins and fungal infections:
Research has made it clear that nitrosamine compounds are extremely strong carcinogens. Animal experiments have shown that nearly 30 nitrosamine compounds can induce esophageal cancer or other organ tumors in animals through oral or parenteral administration. Some people will say, what does this nitrosamine compound have to do with our daily lives? Do we eat this compound in our lives? of course! Because this exists in our daily lives, for example, pickled vegetables, the preference for pickled vegetables is one of the important risk factors for esophageal cancer.
2. Human papilloma virus infection:
Speaking of this virus, it’s famous, but some people don’t quite understand it. In fact, it’s HPV, the virus that causes cervical cancer. HPV infection has the closest and clearest relationship with cervical cancer. , Oropharyngeal cancer is also clearly related to HPV infection, and the incidence of some esophageal cancer is also related to HPV infection. HPV that is closely related to esophageal cancer is mainly type 6, type 16, and type 18.
3. Poor life and eating habits:
As a tumor of the digestive tract, the occurrence of esophageal cancer cannot be separated from bad eating habits. What are the bad eating habits that may increase the risk of esophageal cancer? Smoking, drinking, drinking hot drinks (over 65 degrees Celsius), overeating, often eating outdated and moldy foods, pickled foods, etc.
4. Genetic factors:
When it comes to genetic factors, some people say that esophageal cancer is inherited. In fact, it cannot be simply said that esophageal cancer is inherited. Like other cancers, esophageal cancer is not directly inherited. For example, parents who have esophageal cancer, they inherit esophageal cancer to their children, and their children will get esophageal cancer after birth, or they will get esophageal cancer sooner or later. .
Of course this is not the case. The so-called genetic factors mean that genetic-related factors play a certain role in the occurrence of esophageal cancer, that is, the body’s genetic susceptibility is an internal factor in the pathogenesis. Epidemiological investigations also found that esophageal cancer has obvious differences in geographical distribution and the characteristics of being affected by living environment factors, but even if they live in the same area with a high incidence of esophageal cancer, only some people will get esophageal cancer, and some families often occur Agglomeration phenomenon.
In other words, the onset of esophageal cancer does have a certain genetic susceptibility tendency. To put it bluntly, some people are “inherited” from their parents at birth and are born with a certain “unstable” gene, in the same carcinogenic environment Under the influence of factors, “bad” mutations are more likely to occur, which leads to canceration of normal cells. In other words, the risk of cancer is not necessarily cancer, and people without such factors will also get cancer.
(source:internet, reference only)