November 27, 2022

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Nature: spermidine in semen may be used to treat a genetic defect disease

Nature: spermidine in semen may be used to treat a genetic defect disease


Nature: spermidine in semen may be used to treat a genetic defect disease.   According to a report on the Medicalxpress website, “Nature” recently published an article introducing that scientists have discovered a special genetic disease in which children with protein synthesis defects lead to developmental delay and learning difficulties. This disease can be treated with spermidine. Interestingly, the compound was originally isolated and named from human semen.

Nature: spermidine in semen may be used to treat a genetic defect disease

 

According to Dr. Siddharth Banka, a senior clinical lecturer at the University of Manchester, the ribosome in human cells synthesizes a variety of proteins from the daily intake of amino acids to meet the needs of human development. Genes in the body can instruct ribosomes to synthesize different kinds of proteins. If a certain gene has a congenital defect, it may lead to insufficient protein synthesis and cause specific types of diseases.

Researchers and scientists from France and the United States found a gene mutation called eIF5A in the cells of seven children with developmental delay and learning difficulties. Researchers have confirmed in cell culture and zebrafish experiments that this genetic mutation reduces the ability of ribosomes to synthesize complex proteins in the brain, causing cell growth to slow down and affecting zebrafish head development. Further experiments found that after treatment with spermidine supplements on cells and zebrafish, the adverse effects of genetic defects can be improved.

Spermidine was extracted from human semen (Sperm) by Dutch scientist Leeuwenhoek in 1678. When he found sperm in his semen, he separated a kind of crystal, which is the predecessor of spermidine. In 1888, German chemists Albert Ladenburg and Abel first named it “spermine”. In the 21st century, scientists have discovered the miraculous physiological value of this compound time and time again.

In 2009, researchers Frank Madeo and Tobias Eisenberg of the University of Graz in Austria found in experiments that adding 0.2 millimolar spermidine to the nematode diet increased the life span of the experimental group by 15% compared to the control group. Adding 4 millimoles of spermidine to the yeast test model extended the lifespan of the yeast test group to 400% of the control group.

In 2012, a study in the British Journal of Pharmacology pointed out that oral supplementation of natural polyamines spermidine and spermine can prevent osteoporosis in postmenopausal mice by inhibiting the formation of osteoclasts. There is also evidence that spermidine can improve hormonal regulation of menopause.

In September 2013, a study by “Nature Neuroscience” pointed out that spermidine may prevent age-related memory decline and has the potential to treat Alzheimer’s disease.

In 2014, a study by “Science Advances” showed that by improving the intestinal flora and increasing the level of spermidine and spermine in the blood, it can prevent the aging of the body and brain of mice and extend the life of mice.

In addition, a large number of studies have found that spermidine has a series of effects such as improving cardiovascular disease, preventing cancer and anti-cancer, protecting nerve cells…

In this study, the Banka team discovered for the first time the therapeutic effect of spermidine on a newly discovered genetic disease. He said that thousands of human genetic diseases have now been discovered, and only a small part of them can be identified and treated at an early stage. Our research provides effective diagnosis and treatment methods for patients with eIF5A gene mutations. This type of disease has just been discovered, and the incidence may be one in 10,000 or one in 100,000. There must be many patients waiting for treatment in the UK and around the world. Hope our research results can help them in the future.

Spermidine has such a special medicinal value, so how to make it? It’s really not as complicated as you think! Spermidine is widely present in various tissue cells in the human body. Daily foods such as cheese, mushrooms, soy products, corn or whole grain foods are rich in spermidine, not just semen. Therefore, to extract this compound, no “special” means are needed.

(source:internet, reference only)


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