Nature: Bacterial therapy to treat human eczema!

Nature: Bacterial therapy to treat human eczema!  Nature Sub-Journal: Scientists are expected to develop a bacterial therapy to treat human eczema!

Recently, an article was published in the international journal Nature Medicine entitled “Development of a human skin commensal microbe for bacteriotherapy of atopic dermatitis and use in a phase 1 randomized clinical trial” In the research report, scientists from the University of California and other institutions have studied the use of bacteria to successfully resist the bacteria that accelerate the occurrence of eczema. In the article, the researchers discovered a universal strain from healthy human skin that can be used to help treat eczema, atopic dermatitis.

In the article, the researchers conducted the first human phase 1 double-blind clinical trial to investigate the safety and mechanism of action of this specific bacteria, hoping to use it to help treat patients with eczema. Of the 54 participants, two-thirds Of people report that their body’s disease symptoms have improved, including less pruritus and inflammation. Researcher Richard Gallo said that the main question we want to answer is whether this strategy is safe, and the results of this article are exactly what we hope to find. The eczema symptoms of participants receiving bacterial treatment have improved, and there are no adverse events. .

Researchers have screened more than 8,000 isolates of Staphylococcus on the skin of people who have never had eczema, and identified some strains that can inhibit the growth of Staphylococcus aureus, which is a pathogenic bacteria that can aggravate it. The patient’s skin lesions, such as eczema, etc. The researchers then evaluated other properties of these strains, such as their ability to reduce skin damage and sensitivity to common antibiotics. Finally, they identified a single strain called Staphylococcus hominis A9, which can be used to treat atopic dermatitis.

Researcher Gallo said, this is how we found the universal strain, and this is one of more than 8,000 strains. At the same time, we also tested its ability to kill Staphylococcus aureus and treat atopic dermatitis in a petri dish. ability. Facts have proved that this strategy is effective. In the first test, the researchers tested it in a mouse model of eczema that was given an experimental version. Then they mixed Staphylococcus human in an unscented lotion and applied the mixture to the mice twice a day for continuous After three days of treatment (bacterial therapy), the eczema in the mouse body was basically cured.

The success in the animal model prompted the scientists to launch a phase 1 clinical trial using bacterial therapy to treat 54 patients with eczema; the results showed that two-thirds of the participants had levels of Staphylococcus aureus on their skin There has been a sharp drop, and eczema has improved. Dr. Donald Leung said that in this study, we used a beneficial bacteria as a special method to treat Staphylococcus aureus on the skin of patients with atopic dermatitis. We hope that the results of this article can help eczema patients get rid of the invasion of harmful bacteria that induce inflammation; of course, further research is needed in the later stage to determine whether this newly developed ointment can be used for a long time to reduce the severity of eczema in the patient’s body and improve the patient’s Quality of Life.

Healthy human skin is full of bacteria. The microorganisms living in and on the human body far exceed those of human cells. Most of the microorganisms reside on human skin and will not cause harm to the human body. However, in some people, pathogens are Will negatively affect the health of the body. According to data from the American Eczema Association, nearly 18 million people in the United States suffer from atopic dermatitis, which is the most common form of eczema. Eczema is a chronic, itchy rash that usually appears on the arms, legs, and cheeks.

Finally, the researcher Gallo said that according to our research, we have determined that this reasonable method of treating atopic dermatitis seems to be safe to help treat patients with eczema; and it is relatively simple, because it is only a kind of Ointment, and avoid the side effects of steroids and other drugs that target the host’s immune system.

(source:internet, reference only)

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