December 8, 2021

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These 12 gene mutations are more likely to get breast cancer!

These 12 gene mutations are more likely to get breast cancer!

 

These 12 gene mutations are more likely to get breast cancer!  Big data of 110,000 women found that these 12 gene mutations are more likely to get breast cancer!

These 12 gene mutations are more likely to get breast cancer!


Gene mutations are an important factor in breast cancer. Submitting for screening of mutant genes can better prevent breast cancer.

According to the latest data from the World Health Organization, breast cancer has surpassed lung cancer in 2020, and is the “top chair” in global cancer incidence. There are 2.26 million new cases of breast cancer worldwide, and 1 in 8 newly diagnosed cancer patients has breast cancer.

Fortunately, breast cancer is a cancer with a higher cure rate, and the 5-year survival rate of breast cancer in the United States exceeds 90%. This is inseparable from the popularization of early screening methods such as mammography targets. Breast cancer susceptibility gene detection is also an effective method for early breast cancer screening.

 

Which genes are related to breast cancer?

Recently, a new study published in the New England Journal of Medicine NEJM showed that through the analysis of gene big data of more than 100,000 people, 12 genes were found to be associated with an increased risk of breast cancer.

 


▌What did the big data of 110,000 people discover?

The study included genetic samples of 113,000 women from 25 countries and carried out large-scale genetic testing.

In order to better determine breast cancer susceptibility genes, the research team analyzed the genetic data of 60466 breast cancer patients and 53461 healthy women in the control group, and finally identified 12 genes, namely: ATM, BRCA1, BRCA2, and CHEK2 , PALB2, BARD1, RAD51C, RAD51D, PTEN, NF1, MSH6, TP53.

BRCA1/BRCA2 may be the most familiar breast cancer susceptibility gene. The famous Hollywood actress Angelina Jolie reduced the risk of breast cancer through preventive mastectomy after detecting the BRCA gene mutation;

 

TP53 gene is a common tumor suppressor gene (playing a major regulatory role in the human DNA repair system), and it is also the most relevant gene found to be related to cancer. More than 50% of the increased risk of cancer is related to TP53 gene mutation;

The remaining 9 genes can guide us to find women who have not yet developed cancer but are already at potential cancer risk.

The 12 genes are ranked according to the risk of breast cancer. Among them, women with ATM, BRCA1, BRCA2, CHEK2, and PALB2 gene mutations have a higher risk of breast cancer; while those with BARD1, RAD51C, RAD51D, PTEN, NF1, MSH6 Women with mutations in the TP53 gene are at moderate risk.

It is worth noting that with age, the influence of different genes on the risk of breast cancer also changes. For example, BRCA1, BRCA2, CHEK2, PALB2, PTEN, TP53 gene mutation carriers, the risk of breast cancer will decrease with age. Therefore, young women should pay special attention to these genetic tests.

Different genes are also related to different breast cancer subtypes. For example, estrogen receptor (ER)-negative breast cancer has a higher incidence of BARD1, BRCA1, BRCA2, PALB2, RAD51C, and RAD51D; estrogen receptor (ER) ) Positive breast cancer is related to ATM and CHEK2.

Early prevention, early diagnosis, and early treatment are the three iron laws against cancer. In recent years, new early cancer screening technologies such as liquid biopsy are flourishing. It is believed that more breast cancers will be killed in the cradle in the near future.

 

(source:internet, reference only)


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