May 26, 2024

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Shanghai COVID outbreaking: over 500K people infected and 87 deaths

Shanghai COVID outbreaking: over 500K people infected and 87 deaths


Shanghai COVID outbreaking: over 500K people infected and 87 deaths.


For two consecutive days, more than 20,000 new coronavirus infections were added in a single day in Shanghai, and the epidemic showed a “rebound” trend. Since March, the cumulative number of infected people in the city has exceeded 500,000.


For a large city of nearly 25 million people, that figure means 1 in 50 people is infected with Covid-19. As the number of people infected with the COVID-19 continues to rise, a new problem has emerged – severe illness and death.


Shanghai COVID outbreaking:  over 500K people infected and 87 deaths





87 direct causes of death were underlying diseases or related to COVID directly?


In the past week, the daily number of new deaths in Shanghai has risen significantly.


Since the current round of the epidemic, there have been 87 deaths in Shanghai.

Among the 87 deaths, 48 ​​were males and 39 were females, with an average age of 81.10 years and a maximum of 101 years. However, the exact age distribution was not disclosed.


The above cases were all complicated with severe multi-organ underlying diseases and were in critical condition, including advanced malignant tumors, severe cardiovascular diseases (coronary heart disease, heart failure, hypertension, etc.), neurological diseases (cerebral hemorrhage, cerebral infarction, etc.) , end-stage liver cirrhosis, diabetes, uremia, etc. The immediate cause of death is the underlying disease.


Studies have shown that vaccination plays an important role in preventing infected people from turning into severe disease. In these cases, the COVID-19 vaccination rate was found to be low, and only 5 cases had been vaccinated against the COVID-19 vaccine. ” Zhao Dandan emphasized at the press conference.


The above notification revealed several pieces of information: up to now, most of the 87 deaths were of advanced age and combined with severe underlying diseases, and the direct cause of death was the underlying disease; the vaccination rate was low, and only 5 cases had been vaccinated against the COVID-19.


500,000 cases of infection, 87 deaths, the mortality rate is really not high. However, the case fatality rate was not the only measure of the outbreak during the Omicron epidemic.


As the virus mutated, Omicron’s pathogenicity did drop significantly from previous waves, but it was more transmissible. “During the current epidemic, China, like other countries, has found that if medical resources are sufficient in a pandemic, it can cover the most vulnerable groups such as the elderly and those with severe underlying diseases, and provide them with sufficient medical resources and the best treatment. This will ensure the survival of high-risk groups in the epidemic to the greatest extent possible.”

Only when medical resources are very sufficient can the fatality rate be maintained at a very low level. At the same time, it is the current focus of epidemic prevention to encourage all people of advanced age or those with underlying diseases to be vaccinated, and to improve the antiviral ability of vulnerable groups themselves.


It is worth reminding that the direct cause of death of the 87 patients reported so far is “underlying disease”, which does not mean that the COVID-19 infection did not play a role in the death, and it should still be taken seriously.


Shanghai COVID outbreaking:  over 500K people infected and 87 deaths



Laboratory indicators on the third day of hospitalization may predict the severity of the COVID-19


While doing a good job in the treatment of critically ill patients, how to “move the threshold forward” to prevent the light from becoming serious?


On April 23, a new study mentioned at the European Congress of Clinical Microbiology and Infectious Diseases suggested that “the third day of hospitalization is a turning point in disease progression in symptomatic admitted patients, and it is also the detection of whether patients will develop severe disease. an important hurdle”, or be the answer to this question.


Researchers from the University of Southern California found that “many patients initially require minimal levels of oxygen supplementation, such as nasal intubation, when they first present to the emergency department, but quickly progress to the need for mechanical ventilation.” This means that for For some patients, the progression from infection to severe disease is very fast.


To identify patients “at high risk of developing severe disease” earlier, the researchers surveyed 90 patients hospitalized with COVID-19 pneumonia between March and October 2021. Of these, the median age was 60 years, and 54% were male.


Comparing the severe group and the non-severe group, it was found that on the third day of hospitalization, patients in the severe group had abnormal levels of two host proteins related to the immune response to the COVID-19–interferon-gamma-induced protein 10 (IP-10) and tumor necrosis factor. Apoptosis-inducing ligand (TRAIL).


On the first day of admission, there were no differences in host protein levels between the two groups. But by the third day of hospitalization, the severe group had lower TRAIL levels (median: 21 vs 30 pg/mL) and higher IP-10 levels (median: 713 vs 328 pg/mL) compared with the non-critical group mL). By the fifth day, the IP-10 indicator of critically ill patients was still high.


The investigators concluded that IP-10 levels ≥570 pg/mL and TRAIL levels <25 pg/mL on day 3 of hospitalization were important predictors of COVID-19 pneumonia progression.


Such research results may have reference significance for Shanghai, where the number of critically ill patients is currently increasing. As stated by the authors of this study, “monitoring of Covid-19-related immune proteins can help identify these patients earlier, adjust treatment regimens and levels of care in a timely manner, and effectively control their hyperactive inflammatory response,” thereby reducing the risk of developing severe disease probability.






Shanghai COVID outbreaking: over 500K people infected and 87 deaths

(source:internet, reference only)

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