Reasonable lifestyle can significantly reduce recurrence and death of breast cancer

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Reasonable lifestyle can significantly reduce recurrence and death of breast cancer

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Reasonable lifestyle can significantly reduce recurrence and death of breast cancer.

Patients with high-risk breast cancer maintain a reasonable lifestyle, which is related to a 37% reduction in the risk of recurrence and a 58% reduction in the risk of death!

For diseases such as cancer, it can be said that good living habits are also part of prevention and treatment.

To what extent can adhering to a healthy lifestyle affect the occurrence of cancer? Which lifestyle influences are particularly important?

Recently, a new paper [1] published on JAMA NetWork Open provides a valuable reference for high-risk breast cancer patients.

The results of this prospective cohort study show that mastering the “seven elements” of health, that is, certain exercise, maintaining a healthy BMI, eating a variety of fruits and vegetables, eating less red meat and processed meat, drinking less sugary drinks, not drinking alcohol, not smoking , was associated with a 37% lower risk of breast cancer recurrence and a 58% lower risk of death.

The further analysis of the researchers also pointed out that among the “seven elements”, the living habits that have a greater and less significant impact on breast cancer, I will introduce them in detail later.

The “seven elements” discussed in this study basically come from cancer prevention recommendations regularly issued by the American Institute for Cancer Research (AICR) and the American Cancer Society (ACS). Although it is used for prevention, these healthy lifestyles also have an impact on the prognosis of diagnosed patients.

The researchers used these “seven elements” to design a Lifestyle Index Score (LIS). For each lifestyle, complete compliance was scored as 1, incomplete compliance was scored as 0.5, and complete non-compliance was scored as 0.

The research subjects were from a phase 3 clinical study (S0221), and the participants were high-risk breast cancer patients who had received different chemotherapy regimens. High risk is defined as node-positive, hormone-receptor-negative, tumors larger than 1 cm, or any tumor larger than 2 cm.

In the end, 1340 female patients were included in the study, with a median age of 52.3 years, 52.5% were postmenopausal, 71.2% had completed college education, and 65.3% had hormone receptor-positive breast cancer. During a median follow-up of 7.7 years, 310 disease progressions and 222 deaths occurred.

Dividing the participants into three groups according to the LIS score, it can be clearly seen that the risk of recurrence and the risk of death were significantly reduced in the high-scoring participants . Compared with the lowest group, the highest group had a 37% lower risk of recurrence and a 58% lower risk of death.

Patients with high LIS scores have lower risk of recurrence and death

Looking specifically at the impact of each healthy lifestyle, we can find that the relationship between exercise, non-smoking, eating more fruits and vegetables, drinking less sugary drinks and breast cancer recurrence is more significant , while BMI, drinking alcohol, eating red meat and processed meat were not statistically associated with relapse.

On the other hand, exercise, no smoking, eating more fruits and vegetables, drinking less sugary drinks, eating less red meat and processed meat were significantly associated with lower mortality , while BMI, alcohol consumption and death were not significantly related.

Interestingly, the researchers found that being overweight was associated with a 29 percent lower risk of death.

Relationship between each lifestyle and risk of recurrence and death

This is also consistent with the current mechanism research to a certain extent.

There are many conflicting evidences and hypotheses about the impact of alcohol and obesity on breast cancer survival. Perhaps the relationship between them is not linear, and more detailed research is needed to answer.

Unfortunately, the S0221 trial did not track breast cancer-specific mortality events, so the study endpoint was all-cause death, which means that post-treatment comorbidities, such as cardiovascular disease, a common cause of death in older breast cancer patients, will have some effect. Influence.

However, patients with comorbidities, poor performance status, and low ejection fraction have been excluded from the study design, and the researchers believe that the impact will not be too great.

Although we already have a variety of medical methods to deal with cancer, lifestyle intervention is still a safe, effective, convenient, and cost-effective adjuvant treatment strategy, especially for high-risk patients, which undoubtedly adds a new dimension. very hopeful.

References:

[1] https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2804477

Reasonable lifestyle can significantly reduce recurrence and death of breast cancer

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