A Nose Bacteria (Chlamydia pneumoniae) May Cause Alzheimer’s Disease!

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Important discovery: A Nose Bacteria (Chlamydia pneumoniae) May Cause Alzheimer’s Disease!

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Important discovery: A Nose Bacteria (Chlamydia pneumoniae) May Cause Alzheimer’s Disease!

Chlamydia pneumoniae is a Gram-negative respiratory pathogen that primarily infects the pulmonary and nasal mucosa.

But in recent years, studies have found that it is also associated with other diseases, such as atherosclerosis, asthma, inflammatory arthritis, multiple sclerosis, especially late-onset Alzheimer’s disease.

A bacterium normally found in the nose can sneak into the brain, triggering some of the risk factors that may lead to Alzheimer’s disease, according to new research from Griffith University.

Associate Professor Jenny Ekberg and colleagues from the Menzies Institute of Health Queensland and the Griffith Institute of Medicine, in collaboration with the Queensland University of Technology, found that C. pneumoniae can invade the brain through the nasal nerves .

The bacterium, which usually causes respiratory infections, has also been found in the brain, raising questions: Could it cause damage to the central nervous system ?

The research team conducted extensive research using animal models, not only to discover how Chlamydia pneumoniae enters the brain , but also to figure out the pathological mechanism of Alzheimer’s disease .

The findings, published Feb. 17 in Scientific Reports, are titled: “Chlamydia pneumoniae can infect the central nervous system via the olfactory and trigeminal nerves and contributes to Alzheimer’s disease risk”

https://doi.org/10.1038/s41598-022-06749-9

Associate Professor Ekberg said: “Previous research has shown that several different species of bacteria, including Chlamydia pneumoniae, can rapidly enter the central nervous system within 24 hours through peripheral nerves between the nasal cavity and the brain.

With this knowledge, we We were able to track how Chlamydia pneumoniae infiltrated the blood-brain barrier and quickly entered the brain.”

New research shows that once Chlamydia pneumoniae enters the central nervous system, mouse brain cells respond within days to produce beta-amyloid deposits , a major contributor to Alzheimer’s disease one.

After a few weeks, many gene pathways known to be involved in Alzheimer’s were also significantly activated .

Research has also shown that when C. pneumoniae invades the olfactory nerve , peripheral nerve cells (glial cells) become infected , and these cells are likely to play a supporting role in the survival and spread of C. pneumoniae in the nervous system .

Nasal cavity (NC), olfactory epithelium (OE), olfactory bulb (OB)

“We have long suspected that bacteria, and even viruses, can cause neuroinflammation and ultimately Alzheimer’s disease, however, bacteria alone may not be enough to cause disease in people.

Genetic susceptibility may be required ( genetic susceptibility is Due to different genetic structures, different populations and individuals are prone to polygenic diseases under the influence of the external environment) and the combination of bacteria can lead to Alzheimer’s disease in the long term .” Associate Professor Ekberg added.

Although the study was conducted in mice, humans have the same nerves and can be infected with the same bacteria, so the researchers think the results may apply to humans as well.

Ekberg said the research team has worked with relevant scientific institutions to find drugs that can help glial cells destroy C. pneumoniae that is already present in the brain .

In addition, Professor Ken Beagley of the Queensland University of Technology is developing a vaccine against Chlamydia pneumoniae to reduce its ability to enter the brain .

Reference: https://medicalxpress.com/news/2022-02-bacteria-nose-alzheimer-disease.html

Important discovery: A Nose Bacteria (Chlamydia pneumoniae) May Cause Alzheimer’s!

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