Universal influenza vaccine: Human clinical trials have been carried out
- Why Botulinum Toxin Reigns as One of the Deadliest Poisons?
- FDA Approves Pfizer’s One-Time Gene Therapy for Hemophilia B: $3.5 Million per Dose
- Aspirin: Study Finds Greater Benefits for These Colorectal Cancer Patients
- Cancer Can Occur Without Genetic Mutations?
- Statins Lower Blood Lipids: How Long is a Course?
- Warning: Smartwatch Blood Sugar Measurement Deemed Dangerous
Universal influenza vaccine: Human clinical trials have been carried out
- Red Yeast Rice Scare Grips Japan: Over 114 Hospitalized and 5 Deaths
- Long COVID Brain Fog: Blood-Brain Barrier Damage and Persistent Inflammation
- FDA has mandated a top-level black box warning for all marketed CAR-T therapies
- Can people with high blood pressure eat peanuts?
- What is the difference between dopamine and dobutamine?
- How long can the patient live after heart stent surgery?
Universal influenza vaccine: Human clinical trials have been carried out.
On July 13, 2022, researchers from the National Institutes of Health ( NIH) published a research paper titled: An inactivated multivalent influenza A virus vaccine is broadly protective in mice and ferrets in Science Translational Medicine .
The study developed a universal influenza vaccine consisting of inactivated whole-virus avian influenza subtype A influenza vaccine, which constitutes the majority of current influenza cases.
The vaccine consists of the H1N9, H3N8, H5N1 and H7N3 subtypes, and also includes multiple viral proteins that elicit broad protective B- and T-cell responses.
The vaccine has been shown to protect animal model mice and ferrets against a variety of influenza A viruses , including the 1918 H1N1 strain, the highly pathogenic avian influenza H5N8 strain and H7N9, as well as other strains from humans, avian and swine of potentially lethal influenza strains.
Currently, the vaccine has been approved by the FDA and is undergoing human clinical trials.
The vaccine, which can be administered by injection or intranasally, protects mice and ferrets against a variety of human, swine and avian influenza strains.
Vaccinated animals exhibited significant reductions in viral titers, lung pathology, and host inflammatory responses compared to control animals.
The way the vaccine is made is similar to how seasonal flu vaccines are currently produced, meaning it could be relatively simple and inexpensive to make this universal vaccine candidate.
In addition, no toxicity was observed in mice, ferrets or rabbits that received the vaccine, suggesting that the vaccine candidate may be safe in humans, subject to further validation in clinical trials.
At present, the universal influenza vaccine has been approved by the FDA for human clinical trials, and a phase 1 clinical trial aimed at verifying safety and immunogenicity was launched at the NIH Clinical Center in June this year.
For years, researchers around the world have been trying to develop a universal flu vaccine that would save scientists and pharmaceutical companies from predicting circulating strains and redesigning the vaccine each year.
The new vaccine candidate could be widely used as a pre-epidemic flu vaccine and a super-seasonal flu vaccine, and the vaccine is inexpensive and easy to distribute globally, according to the authors of the paper.
Paper link :
https://www.science.org/doi/10.1126/scitranslmed.abo2167
Universal influenza vaccine: Human clinical trials have been carried out.
(source:internet, reference only)
Disclaimer of medicaltrend.org
Important Note: The information provided is for informational purposes only and should not be considered as medical advice.
