June 24, 2022

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What diseases you may suffer from high lactate dehydrogenase?

What does the level of lactate dehydrogenase mean? 



 

What diseases you may suffer from high lactate dehydrogenase? 

 

Lactate dehydrogenase (LDH) is an isoenzyme that catalyzes the mutual conversion of lactic acid and acetone, and belongs to hydrogen transferase.

The enzyme exists in the tissues of all animals, with the highest activity in the liver, followed by the heart, skeletal muscle, and kidney. It can also be detected in tumor tissues and leukemia cells.

 

In most animal tissues, it is five kinds of tetramers composed of two peptide chains in a certain ratio. Each of its peptide chains is coded by a gene, and after transcription, translation, modification and processing, it finally becomes a biologically active substance.

Different animals, different tissues or organs have their specific isoenzyme profiles at different developmental stages or different life cycles. There are two lactate dehydrogenases, L and D, in nature.

 

 

 


What diseases you may suffer from high lactate dehydrogenase?

 

There are the following aspects:

1. When the condition of hepatitis B virus carriers deteriorates into hepatitis B patients, some liver cells are damaged, and the levels of LDH4 and LDH5 in the serum will increase to varying degrees.

2. The treatment of hepatitis B, especially improper medication, can cause nephrotoxicity when taking the same medication for a long time. When nephrotoxicity occurs, the content of lactate dehydrogenase in the serum will rise rapidly.

3. If hepatitis B is not treated properly and actively, it will cause severe abnormal liver metabolism when it develops to a certain extent, leading to kidney failure, which will also cause the content of lactate dehydrogenase to increase.

4. Pulmonary infarction, pernicious anemia, shock and tumor metastasis caused by pleural and ascites fluid can cause lactate dehydrogenase

 

 

 


Elevated: LDH measurement is commonly used to diagnose myocardial infarction, liver disease and certain malignant tumors

 

(1) Myocardial infarction

The onset of symptoms increased in 10-12 hours, reached a peak in 24-8 hours, and returned to normal after 8-9 days. Compared with CK, although the enzyme activity appears later and the positive rate is lower, it lasts for a long time, and the degree of increased activity is closely related to the condition of myocardial infarction.

The larger the infarct range, the higher the enzyme activity. If the LDH increases and the recovery is delayed, or if it increases again during the course of the disease, it indicates that the infarct size is enlarged and the prognosis is poor.

 

(2) Liver disease

Acute hepatitis or chronic active hepatitis LDH is often significantly or moderately elevated. Its sensitivity is slightly lower than ALT. LDH activity is significantly increased in liver cancer, especially in metastatic liver cancer. Up to 1000 U/L.

 

(3) Blood disease

LDH activities such as leukemia, megaloblastic anemia, and malignant lymphoma are elevated.

 

(4) Other

Malnutrition, striated muscle injury, pancreatitis, pulmonary infarction and other LDH activities also increase.

 

 

 


Common reasons for reduction are as follows:

1. Endocrine disorders;

2. Too tired, poor sleep, bad mood, etc.

 

In short, low lactate dehydrogenase is generally not very serious, and it can be recovered after conditioning.

However, if the lactate dehydrogenase is too high, attention should be paid. Because of pulmonary infarction, pernicious anemia, shock and tumor metastasis caused by pleural and ascites fluid, it will cause high lactate dehydrogenase.

 

 

 

 

 

What does the level of lactate dehydrogenase mean? 

(source:internet, reference only)


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