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More than you can imagine: What diseases does Stem Cell Therapy treat?
More than you can imagine: What diseases does Stem Cell Therapy treat? The field of stem cell therapy and breakthroughs are powerful than you can imagine!
In recent years, scientists around the world have made some new breakthroughs in the application of mesenchymal stem cells in the field of disease treatment.
“The clinical application of stem cell technology represents a major direction for future medical development.”
Adult stem cells are the most mature type of clinical application. Hematopoietic stem cells and mesenchymal stem cells are all adult stem cells. Among them, mesenchymal stem cells are also the main members of the stem cell family, and they have attracted more and more attention because of their multi-directional differentiation ability and immunomodulatory effects.
The following are some of the new breakthroughs that global scientists have made in the field of mesenchymal stem cell application in disease treatment in recent years.
In Canada and the United States, BPD affects approximately 10,000 extremely premature newborns each year. The lungs of these babies are not sufficiently developed, so they must receive oxygen through a ventilator. However, the combination of mechanical ventilation and oxygen can damage the lungs and further prevent their development. In addition, long-term staying in the neonatal intensive care unit will also affect the normal development of other parts of the newborn’s body (including the retina, kidney and brain).
In this study, the researchers used the lung development of newborn rats to simulate the lung development of premature newborns born in the 24th week, and finally obtained some very important findings. In the next two years, Dr. Thébaud wants to conduct prospective studies on 20 patients to verify the feasibility and safety of this stem cell therapy. Bring new life to patients.
Mesenchymal stem cell treatment of animal models of Alzheimer’s disease lasted for two years and achieved relatively satisfactory results. This means that stem cell therapy can effectively slow down or prevent the development of Alzheimer’s disease, and even reverse the damage caused by Alzheimer’s disease.
The report pointed out that after the animals in the treatment group received intravenous injection of mesenchymal stem cells, there was an effective reduction in beta amyloid in the brain. Amyloid β is a pathogenic protein that exists in the brain cells of patients with Alzheimer’s disease. It has strong neurotoxicity and is the main cause of degeneration and death of neurons in the brains of patients with Alzheimer’s disease and around the senile plaques.
“The results of this preclinical study show that stem cells have the ability to reduce the increase in senile plaques in the brain tissue of patients with Alzheimer’s disease, and are completely comparable to the best beta amyloid treatment drugs. This therapy also does not cause any such as cerebral amyloid angiopathy. And brain microhemorrhage and other adverse events.
It is now generally believed that after middle age, many physiological activities in the body begin to go “downhill.” The blood circulation function declines, the metabolism slows down, the cells and tissues gradually degenerate and age, and the unsaturated fatty acid in the diet is oxidized and combined with protein, it will form a brown-black “lipofuscin” deposited in the cells. The aging tissues and cells can no longer exclude these brown-black particles. They accumulate in large amounts in the skin, forming age spots.
Stem cells can differentiate into a variety of tissue cells, replacing and repairing damaged and aging human cells, as the third type of diagnosis and treatment technology after drugs and surgery.
The pluripotent stem cells of the umbilical cord are commonly used in this field, and the medical name is umbilical cord mesenchymal stem cells. It has high purity and strong proliferation ability. It can differentiate into hepatocytes, nerve cells, pancreatic islet secretory-like cells and other cells; it has immune system, endocrine system, and nervous system regulation; it can replace and repair diseased, damaged and aging human bodies Cells and human tissues.
In the field of medical cosmetology, there are many areas where stem cell technology can exert powerful effects, such as removing stretch marks, improving postpartum pigmentation, removing scars, and skin burns.
Female childbirth injuries
Mesenchymal stem cell transplantation can treat female childbirth injuries without rejection. Natural childbirth may cause harm to the mother, leading to “stress incontinence”. According to statistics, 4% to 35% of women who give birth naturally are affected by this problem. The existing physical therapy and surgical treatment are not very effective.
By transplanting mesenchymal stem cells, female mice were used to simulate childbirth injuries in the laboratory, helping them repair damaged organs and effectively promoting the controllability of urination.
“Stem cell therapy may be more feasible and non-invasive than the current common treatments. Our research reveals a potential postpartum repair method and can effectively treat stress urinary incontinence in elderly women.
For highly disabling skin ulcers, cell therapy, including mesenchymal stem cell therapy, is a very effective new treatment method.
Skin healing is a dynamic process, including complex feedback from multiple types of cells to different growth factors. Even the latest wound healing treatments and surgical procedures have a failure rate of up to 50%.
But by regulating the local response of inflammation, inducing cell replacement and paracrine methods, mesenchymal stem cells have become an effective therapy for wound healing.
Intervertebral disc fibrosis
Intervertebral disc fibrosis is the main cause of disability, which seriously affects the quality of life of patients and brings a heavy burden to society. Up to now, the disease lacks effective intervention measures.
Studies have found that after implantation of mesenchymal stem cells, they can regulate the production of collagen fibrils and strengthen tissue regeneration in fibrotic diseases, which provides a new and effective treatment for reducing intervertebral disc fibrosis.
Elderly muscle function recovery
Studies have shown that mesenchymal stem cells help to resist the recovery of skeletal muscle damage after exercise.
The researchers injected mesenchymal stem cells into the mouse’s leg muscles before eccentric exercise (similar to the lengthening and contraction in human resistance training) to increase the probability of repair and enhance the growth and strength of the mouse muscles during exercise.
Skeletal muscle is a very complex organ, densely packed with nerves and blood vessels. Unfortunately, all these different tissues become dysfunctional with age. Therefore, interventions should be developed to reverse the age-related muscle mass and function. The decline is necessary. Mesenchymal stem cells are very suitable for this task because of their ability to repair a variety of different tissue types.
Mesenchymal stem cells can differentiate into many different cell types. They also secrete growth factors, which stimulate muscle precursor cells (called satellite cells) to expand in internal tissues and promote repair after injury.
Cognitive impairment after stroke
In stroke patients, small blood clots in the brain block blood vessels, leading to cerebral ischemia, which can cause cognitive impairment, including cognitive decline, executive dysfunction, depression, apathy, and decreased emotional intelligence. In severe cases, vascular dementia occurs, which is usually the symptoms of “patients becoming stupid and not knowing relatives”.
Carriers for tumor treatment
Tumors are considered to be “unhealing wounds.” Some anti-tumor drugs that are widely used clinically have a short half-life, and their application doses in the treatment of tumors are often high, which brings serious side effects to patients. However, after the implementation of tumor-targeted therapy through mesenchymal stem cells, a better therapeutic effect can be achieved while significantly reducing the dose of clinically applied drugs.
Natural heart repair
Studies have found that stem cell technology can increase the production of adult cardiomyocytes and stimulate existing stem cells to mature and transform into heart cells.
Stem cell therapy can stimulate the proliferation of dormant and surviving host heart tissue and attract stem cells to the heart. The resulting new type of cardiac muscle tissue has complete functions and persistence.
Although primitive stem cells cannot respond to the normal replacement of missing visceral cells, they can promote the reconstruction of heart tissue after a patient has a heart attack.
This means that existing heart cells can promote the formation of new heart cells and allow new cells to replace dead cells. This cyclic process can change with the severity of a heart attack, so that existing heart cells can assist in the development of new cells. In the future, these effects can be expanded through stem cell therapy to improve the structure and function of the human heart.
(source: internet, reference only)
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