Pfizer COVID Vaccine Latest Side effects exposed: Or cause Hepatitis-Liver Cirrhosis-Liver Failure
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Pfizer COVID Vaccine Latest Side effects exposed: Or cause Hepatitis-Liver Cirrhosis-Liver Failure
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Pfizer COVID Vaccine Latest Side effects exposed: Or cause Hepatitis-Liver Cirrhosis-Liver Failure
Recently, Pfizer just released the second vaccine data, which once again caused heated discussions and discussions on the entire Internet. The surge in adverse reactions made many people worry about the safety of Pfizer’s vaccine.
And recently, scientists have made new discoveries about the potential side effects of Pfizer’s vaccine!
The latest clinical research from Germany found:
The COVID-19 mRNA vaccine (BNT162b2) jointly developed by Pfizer/BioNTech may cause a rare T cell-mediated autoimmune hepatitis!
Autoimmune hepatitis is a chronic progressive liver inflammatory disease mediated by autoimmune reactions. Its clinical features are elevated serum transaminases, hypergamma-globulinemia, positive autoantibodies, and histological features are lymphocytes. , plasma cell infiltration-based interface hepatitis.
Severe cases can rapidly progress to cirrhosis and liver failure.
The above research was published on April 21 in the Journal of Hepatology, an international authoritative journal in the field of liver disease. .
The clinical study reportedly disclosed a bimodal flare of acute hepatitis following two doses of Pfizer’s mRNA vaccine, with flares occurring after both vaccinations.
The male patient in the study was 52 years old and had no medical history other than hypothyroidism.
The study found that the male patient developed jaundice 10 days after the first dose of mRNA vaccine, and liver function tests (LFT) showed acute mixed hepatocellular/cholestatic hepatitis.
On day 25 of vaccination, the patient was hospitalized for treatment.
Subsequently, 41 days after the first vaccination, the patient received a second dose of the BNT162b2 vaccine. And 20 days after the second vaccination, the patient developed symptoms such as fatigue and nausea, and laboratory tests showed that he had a recurrence of acute mixed hepatitis.
The patient was transferred to a tertiary care center for treatment 26 days after the second vaccination.
To find the cause of the patient’s hepatitis, the researchers performed serological, polymerase chain reaction (PCR) tests on the patient to rule out hepatitis A, B, C or E, cytomegalovirus (CMV) and Epstein -Possibility of Barr virus infection.
Autoimmune serology showed mild hyperglobulinemia, borderline positive for antinuclear antibody (ANA), antimitochondrial M2 antibody (AMA-M2), and antismooth muscle antibody, but negative for LKM antibody.
The investigators then performed a liver biopsy from the patient and found that the patient’s hepatitis had moderate lymphoplasmacytic infiltration and foci of lobular necrosis and apoptosis.
The 52-year-old’s symptoms were consistent with autoimmune hepatitis, the researchers said.
Based on the study of various factors, the research team believes that the vaccination of BNT162b2 may cause immune-mediated hepatitis through the cellular immune mechanism triggered.
These results suggest that T cells are the key pathogenic immune cell type in this vaccine-associated immune hepatitis, a novel subtype of autoimmune hepatitis.
Pfizer COVID Vaccine Latest Side effects exposed: Or cause Hepatitis-Liver Cirrhosis-Liver Failure
(source:internet, reference only)
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