June 25, 2024

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Researchers use newborn heart stem cells to treat Crohn’s disease

Researchers use newborn heart stem cells to treat Crohn’s disease


Researchers use newborn heart stem cells to treat Crohn’s disease.

Researchers injected mice with neonatal stem cells extracted from heart tissue discarded after surgery and found that the therapy reduced gut inflammation and improved healing, offering a new alternative treatment for chronic inflammatory conditions such as Crohn’s disease .

Stem cells’ ability to transform — differentiate — into any cell type and repair damaged tissue means that stem cell therapies have been used to treat autoimmune, inflammatory, neurological and orthopedic diseases.


Researchers use newborn heart stem cells to treat Crohn's disease



Different types of stem cells, including hematopoietic stem cells (which develop into blood cells), mesenchymal stem cells (which make and repair cartilage, bone and bone marrow fat) and induced pluripotent stem cells, have been used in clinical trials and medical treatments.

In a new study, researchers at Ann and Robert H. Lurie Children’s Hospital of Chicago extracted neonatal mesenchymal stem cells (nMSCs) from discarded heart tissue and Use it as a novel therapy for enteritis.


Arun Sharma, corresponding author of the study, said: “Neonatal cardio-derived mesenchymal stem cells have been used in clinical trials to repair injured hearts, but this is the first time they have been used in a model of inflammatory bowel disease. study these potent cells. Our findings are encouraging and certainly provide a new platform for the treatment of chronic inflammatory bowel disease.”


Previous studies have shown that mesenchymal stem cells (MSCs) taken from one person and used in another (allogeneic stem cells) are a safe and effective way to treat certain immune diseases.

But studies have also shown that mesenchymal stem cells taken from older patients are less capable of differentiating than cells taken from younger people.

So the researchers used neonatal cells, or cells taken from newborns up to four weeks after birth.


During heart surgery on newborns with congenital heart disease, part of the thymus gland (the organ that sits above the front of the heart and makes white blood cells) is removed and discarded.

The discarded tissue is a good source of mesenchymal stem cells.


In the current study, the researchers injected these heart-derived nMSCs directly into Crohn’s disease-like inflammatory foci in the small intestine of mice.

They found that after the injection, the inflammation of the lesion was significantly reduced and the wound healing of the intestinal mucosa was promoted.


Chronic inflammatory bowel diseases such as Crohn’s disease are often treated with a combination of corticosteroid anti-inflammatory drugs, antimicrobials, immunosuppressants, and antibody therapy.

However, the combination can produce side effects, and some patients develop resistance. The researchers say their new treatment could address some of these problems side by side.


Since nMSCs are injected directly into the gut, current treatments require surgery.

The next step for the researchers is to develop a method for administering the stem cells intravenously. More animal experiments are needed before this treatment can enter clinical trials.


“Ultimately, our goal is to use this cell type as a therapy before the symptoms and signs of Crohn’s disease appear, but also as a preventative measure,” Sharma said. “We may also apply this approach to other diseases.”

Inflammatory diseases. The potential is enormous and we are excited to move forward.”

The study was published in the journal Advanced Therapeutics.






Researchers use newborn heart stem cells to treat Crohn’s disease

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