June 14, 2024

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Young Plasma Dramatically Reverses Organ Aging and Age-Related Cognitive Decline

Young Plasma Dramatically Reverses Organ Aging and Age-Related Cognitive Decline



Young Plasma Dramatically Reverses Organ Aging and Age-Related Cognitive Decline

Aging is a complex, multi-stage, and progressive process that occurs throughout one’s life.

As time passes, the organs and muscles in the human body gradually age, and some diseases, including cancer, diabetes, and cardiovascular diseases, become more prevalent with age.

Rejuvenation and turning back the clock on aging have long been considered challenging goals in the scientific community.

Although they remain distant objectives, ongoing research in the field of longevity and health offers hope for a healthier and longer future for humans.

On July 27, 2023, researchers from Harvard Medical School published a study titled “Multi-omic rejuvenation and life span extension on exposure to youthful circulation” in the journal Nature Aging. This study demonstrated that after three months of heterochronic parabiosis between young and old mice, the lifespan of the older mice was extended by 10%, and there was a significant reduction in the epigenetic age of their blood and liver.

However, these experiments involved animals of the same species, raising the question of whether cross-species plasma transfer could also reverse biological age.

On October 24, 2023, researchers from the University of California, Los Angeles, published a study in the journal GeroScience titled “Reversal of biological age in multiple rat organs by young porcine plasma fraction.”

This research revealed that treating elderly rats with exosome components from young pig blood led to an average reversal of 67.4% in their epigenetic age. If these results were applicable to humans, it would be equivalent to an 80-year-old person reverting to the age of 26.

Young Plasma Dramatically Reverses Organ Aging and Age-Related Cognitive Decline

In this study, exosome components from young pig plasma, composed of complex nanostructures, including exosomes, were injected into elderly rats via intravenous infusion. Exosomes are tiny vesicles secreted by cells and carry various molecules, including RNA and proteins. The therapeutic effects on liver tissue, blood, heart, and hypothalamus were measured using six different epigenetic clocks, and changes in the epigenome were analyzed to determine biological age.

The researchers divided 18 male rats into three groups: one group of six young rats (30 weeks old), a second group of six elderly rats (109 weeks old), and a third group of six elderly rats treated with E5 (109 weeks old).

The elderly rats received two intravenous injections of E5, with the first treatment lasting eight days and the second treatment taking place 95 days later, spanning a total of 155 days.

The study found that E5 treatment for elderly rats significantly reduced the epigenetic age of their blood, liver, and heart, bringing it to a level similar to that of young rats.

Specifically, based on six epigenetic clocks, E5 treatment led to an average reversal of 74.6% in liver tissue, 64.3% in blood, 46.5% in heart tissue, and 24.4% in the hypothalamus.

Furthermore, when the DNA methylation profiles of untreated control group rats were included in the analysis, the reversal effect became even more pronounced, with liver tissue at 77.6%, blood at 68.2%, heart at 56.5%, and the hypothalamus at 29.6%. The average reversal of epigenetic age for these four tissues was 67.4%.

Young Plasma Dramatically Reverses Organ Aging and Age-Related Cognitive Decline

Rejuvenation effect of E5 treatment

The researchers stated that E5 treatment resulted in a reduction of over half in epigenetic age. If these findings were applicable to humans, it would be akin to an 80-year-old person reverting to the age of 26.

Moreover, the researchers analyzed parameters such as lipid levels, blood glucose, and creatinine and found significant improvements after treatment, with parameters matching those of the young control group at the end of the experiment.

Young Plasma Dramatically Reverses Organ Aging and Age-Related Cognitive Decline

Improvement of blood lipids, blood sugar, creatinine and other parameters

In terms of inflammation, pro-inflammatory cytokine levels sharply decreased after the first treatment, increased briefly, and then decreased again after the second treatment, remaining stable until the end of the study. Oxidative stress markers and liver and kidney function markers in elderly rats also returned to levels comparable to those of young rats at the end of the study.

In summary, these results indicate that the administration of exosome components from young pig plasma can reverse the epigenetic age of multiple organs in rats. Cross-species treatment with exosomes from young blood plasma shows significant potential for reducing the epigenetic age of several rat organs, reducing chronic inflammation and oxidative stress markers.

Link to the paper:

Young Plasma Dramatically Reverses Organ Aging and Age-Related Cognitive Decline

(source:internet, reference only)


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