March 2, 2024

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mRNA Vaccines May Generate Unexpected Proteins and Impact Unknown!

Nature Breakthrough: mRNA Vaccines May Generate Unexpected Proteins and Impact Unknown!



Nature Breakthrough: mRNA Vaccines May Generate Unexpected Proteins and Impact Unknown!

During the COVID-19 pandemic, mRNA vaccines were swiftly approved for use to expedite vaccination efforts, with billions of doses administered globally. The safety and potential implications of mRNA vaccines have been the subject of ongoing debate due to their rapid deployment, and definitive answers have remained elusive.

As the JN.1 variant continues to spread globally, on December 6, Nature published a groundbreaking paper titled “N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting,” drawing intense attention from scholars worldwide.

Nature Breakthrough: mRNA Vaccines May Generate Unexpected Proteins and Impact Unknown!

Here is the key finding: mRNA vaccines may induce the production of a small amount of unexpected proteins. Currently, there is no research evidence indicating whether these erroneous proteins pose a threat to the safety of mRNA vaccines, and the potential impacts on the human body remain unknown.

Decades ago, scientists envisioned using mRNA to create vaccines by modifying a base in the mRNA sequence. This modification involved substituting pseudouridine for uridine, making the mRNA more stable, enabling cells to produce the desired proteins and prompting the human body to generate corresponding antibodies. This breakthrough accelerated the development of potential mRNA vaccines and therapies, earning the researchers a Nobel Prize.

However, Nature’s new study reveals flaws in the mRNA modification strategy.

We know that ribosomes sometimes mistranslate natural mRNA, typically resulting in the production of inactive proteins that are promptly degraded by cells. In this study, mRNA with pseudouridine, used in COVID-19 vaccines, was found to be more prone to inducing codon decoding errors compared to mRNA with normal uridine. Approximately 8% of the proteins produced by experimental mRNA exhibited decoding errors.

To test if a similar effect occurs in the human body, the research team compared the immune responses of mice vaccinated with mRNA and adenovirus vaccines. The results showed that mice vaccinated with mRNA produced antibodies against erroneously derived proteins, while those vaccinated with adenovirus did not produce such antibodies.

Subsequently, the researchers examined the immune responses of 20 individuals vaccinated with adenovirus and 21 individuals vaccinated with mRNA. About one-third of mRNA vaccine recipients showed immune responses to misfolded proteins, while none of the adenovirus recipients exhibited such responses.

Nature Breakthrough: mRNA Vaccines May Generate Unexpected Proteins and Impact Unknown!

Anne Willis and James Thaventhiran of the University of Cambridge and their team emphasized that the results do not indicate the safety of COVID-19 mRNA vaccines. They pointed out that naturally occurring decoding errors often happen when infected cells produce virus proteins, and these erroneous proteins can naturally enhance the body’s immune response, potentially even boosting the effectiveness of S protein vaccines against COVID-19.

Stephen Griffi of the University of Leeds remarked, “This groundbreaking study provides us with a new perspective on how cells use natural and artificial mRNA to manufacture proteins. Beyond vaccines, RNA technology’s future broader therapeutic applications may involve higher and more frequent doses, necessitating the resolution of any and all potential issues.”

What are your thoughts on these findings?

Nature Breakthrough: mRNA Vaccines May Generate Unexpected Proteins and Impact Unknown!

(source:internetUBVoa1PiaA0uOXuH2uXb6Q, reference only)


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