New study found surprising link between gum disease and Alzheimer's disease

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New study found surprising link between gum disease and Alzheimer’s disease

New study found surprising link between gum disease and Alzheimer’s disease.

Targeting the bacteria that cause periodontal disease can slow the progression of Alzheimer’s, according to researchers at Tufts University‘s School of Dentistry.

Fusobacterium nucleatum frequently reproduces in periodontal disease.

It affects the jawbone and gums and can lead to tooth instability and tooth loss if left untreated.

In recent years, Rhizobacter nucleatum has been linked to a variety of diseases – including premature birth and colorectal cancer.

New study found surprising link between gum disease and Alzheimer's disease

Now, a new study by Tufts University researchers and colleagues sheds light on the link between sclerotium nucleatum and Alzheimer’s disease.

Their findings were published in Frontiers in Aging Neuroscience.

“In this study, our lab has shown for the first time that Rhizobacter nucleatum can produce systemic inflammation that even infiltrates nervous system tissue and exacerbates the signs and symptoms of Alzheimer’s disease,” says periodontist at Tufts University School of Dentistry. said Jake Jinkun Chen, professor of science and director of the oral biology department.

Rhizobacter can also cause severe systemic inflammation, which is a symptom of many chronic diseases, such as type 2 diabetes and Alzheimer’s disease, according to Chen.

Chen and his colleagues hope to slow the spread and progression of at least two epidemics by targeting R. nucleatum: periodontal disease, which affects 47 percent of U.S. adults over the age of 30; Alzheimer’s disease, which currently Affects 6.5 million Americans, but is projected to reach more than 14 million by 2060.

Prismella nucleatum and immune cells in the brain

New research in mice shows that Prismella nucleatum causes abnormal proliferation of microglia, the immune cells in the brain that are normally responsible for clearing damaged neurons and infections and helping maintain the central nervous system of overall health.

The researchers found that this oversupply of microglia also contributed to an increased inflammatory response.

Chronic inflammation or infection is thought to be a key determinant of cognitive decline that occurs during Alzheimer’s disease progression.

“Our study shows that Prismella nucleatum can reduce memory and thinking abilities in mice through certain signaling pathways. This is a warning sign for both researchers and clinicians,” Chen said.

In the past, scientists have suggested a possible link between periodontal disease and Alzheimer’s.

Chen believes that while the new study does not show evidence that periodontal disease associated with nucleophilus directly causes Alzheimer’s disease, the new study suggests that periodontal disease caused by nucleobacillus can be untreated or poorly treated if left untreated. , it may worsen the symptoms of Alzheimer’s disease.

Conversely, effectively treating periodontal disease in those with early Alzheimer’s disease may slow the progression of Alzheimer’s disease.

“Testing bacterial load and symptom severity could one day be a way to measure the impact of nucleic acid bacteria and manage treatments to slow the progression of periodontal disease and Alzheimer’s disease,” Chen said.

In addition, their study also suggests potential drug targets that can specifically inhibit local and systemic inflammation caused by nucleic acid bacteria in the periodontal environment.

Oral Infections and Systemic Diseases

More broadly, Chen and his colleagues aimed their translational research at blocking the pathway between periodontal disease and Alzheimer’s and other diseases associated with inflammation, including type 2 diabetes.

Only 2% of mRNA is translated into protein. 98% of RNA is “non-coding”, traditionally considered “junk genes”. But a growing number of scientists — including Chen — are discovering an important function they possess.

In particular, his lab focuses on two types of noncoding RNAs: one is microRNA, which regulates the production of proteins in cells.

The other -lncRNA- exerts other functions to regulate gene expression and can ultimately be used in the treatment of arteriosclerosis and periodontal disease, diabetes, cancer and diabetic bone disease.

Research by Chen’s lab shows that a molecule called microRNA-335-5P can inhibit damage caused by periodontal pathogens.

The molecule may also have a powerful role in targeting the pathological molecules produced in the brain that lead to Alzheimer’s.

“In general, microRNAs suppress gene expression and can prevent the production of certain proteins, in particular MicroRNA-335-5P can target three ‘bad’ genes — DKK1, TLR-4 and PSEN-1, which are all blocked by thought to be related to Alzheimer’s disease,” Chen said.

In addition, his lab has designed a small molecule called adipoAI, which has powerful anti-inflammatory properties.

Chen hopes to soon begin a clinical trial to see if it could be effective in treating a range of inflammatory diseases — including type 2 diabetes, Alzheimer’s disease and periodontal disease.

In the end, he concluded: “Your mouth really is the door to your body.”

New study found surprising link between gum disease and Alzheimer’s disease

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