August 17, 2022

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500ml of sugary drinks per day doubles the risk of colorectal cancer!

500ml of sugary drinks per day doubles the risk of colorectal cancer!



 

500ml of sugary drinks per day doubles the risk of colorectal cancer!

The milk tea that girls drank when they were young has become a hidden danger of cancer before the age of 50!

According to the latest “Global Cancer Statistics Report 2020” published by the International Cancer Research Team IARC, colorectal cancer currently ranks third in the global incidence spectrum and second in the death cause spectrum, accounting for 10.0% and 9.4% of the total number of cancer incidences and deaths, respectively. .

 

Whether in high-income countries or middle-income and low-income countries, the incidence of colorectal cancer in people under 50 years of age, that is, early-onset colorectal cancer, has increased significantly in the past few decades.

 

In Australia, the incidence of colon cancer and rectal cancer among young people aged 20-29 years has increased at a rate of 9.3% and 7.1% per year, respectively, during the decade from 2004 to 2014.

People born in the 1990s in the United States have twice and four times the risk of colon cancer and rectal cancer, respectively, than those born in the 1950s.

 

Behind the increased risk of colorectal cancer among young people, it is inseparable from the modern lifestyle, including diet and living habits, to fuel the flames.

 

In the decades when the incidence of early-onset colorectal cancer has increased, the consumption of sugar-sweetened beverages has also increased sharply.

Taking the data from the United States as an example, the average intake of sugar-sweetened beverages in the second half of the 20th century in the United States is compared with the previous , An increase of 500% !

Young people between the ages of 20-34 consume an average of 1.7 servings or 402 ml of beverages per day (1 serving = 8 ounces = 236.56 ml).

 

Sugar-sweetened beverages consumed during adolescence and adulthood will have a life-long impact on health.

After adulthood, drinking one more sugar-sweetened beverage a day will increase the risk of obesity by 12% and the risk of type 2 diabetes by 18%. Obesity and diabetes are both It is a known risk factor for colorectal cancer .

 

So, is the increase in the incidence of early-onset colorectal cancer also related to the increase in the intake of sugary drinks in young people?

 

After analyzing and investigating the dietary intake and early-onset colon cancer incidence data of nearly 100,000 female nurses in the United States from 1991 to 2015, researchers at Harvard University and the University of Washington finally confirmed this conjecture: adolescence and adulthood The intake of sugar-sweetened beverages is closely related to the onset of early-onset colorectal cancer .

The study was published this year in Gut, a top journal in the field of gastroenterology.

 

500ml of sugary drinks per day doubles the risk of colorectal cancer!

 

Over 24 years, 109 cases of early-onset colorectal cancer occurred among 95,464 surveyed women.

 

After adjusting for other factors that may affect the incidence of colorectal cancer, including family history of colorectal cancer, smoking history, drinking history, physical activity, red meat and processed meat consumption, etc., sugary beverages have an effect on early-onset colorectal cancer. The impact of cancer is still significant.

 

In adulthood, women who consume ≥2 servings (473.12ml)/day of sugar-sweetened beverages are at 2.18 times the risk of early-onset colorectal cancer than women who consume less than 1 serving/week (RR 2.18; 95% CI 1.10-4.35; p=0.02) , consuming one more sugar-sweetened beverage (236.56 ml) a day increased the risk of early-onset colorectal cancer by 16% (RR 1.16; 95% CI 1.00-1.36).

 

500ml of sugary drinks per day doubles the risk of colorectal cancer!

Legend: Adulthood sugar-sweetened beverage intake and the risk of early-onset colorectal cancer

 

In addition, in this prospective cohort study, another 41,272 women recalled their dietary intake during adolescence (13-18 years of age) in 1998. Based on these records, the researchers also found that:

 

During adolescence, women who consume ≥ 2 servings of sugar-sweetened beverages per day have 3.41 times the risk of early-onset colorectal cancer (RR 3.41; 95% CI 1.08-10.8; p=0.01), consuming one more sugar-sweetened beverage a day increased the risk of early-onset colorectal cancer by 32% (RR 1.32; 95% CI 1.00-1.75).

 

500ml of sugary drinks per day doubles the risk of colorectal cancer!

Legend: 13-18 years old sugar-sweetened beverage intake and the risk of early-onset colorectal cancer

 

In this study, the researchers also found that the intake of sugar substitute beverages and fruit juices has little to do with early-onset colorectal cancer. One cup of sugar substitute beverage/coffee/skimmed milk/whole milk was used instead of one cup of sugary beverage every day. , Can reduce the risk of early-onset colorectal cancer by 17%-36% (sugar substitute drinks: RR 0.83; 95% CI 0.69 to 0.99; coffee: RR 0.82; 95% CI 0.68 to 0.99; skimmed milk: RR 0.65; 95 % CI 0.47 to 0.90 and whole milk: RR 0.64; 95% CI 0.46 to 0.89).

 

500ml of sugary drinks per day doubles the risk of colorectal cancer!

 

Purified water and tea instead of sugar-sweetened beverages also have a tendency to reduce the risk of early-onset colorectal cancer, but they did not reach statistical significance in this study.

 

This study revealed that the intake of sugar-sweetened beverages during adolescence and adulthood promotes the occurrence of early-onset colorectal cancer in young people, and that replacing sugar-sweetened beverages with coffee, milk, and sugar substitute beverages can reduce the risk of this disease .

 

It is known that calcium supplementation can reduce the occurrence of colorectal cancer. It should be reminded that the health effects of sugar substitute drinks are still controversial, and they should not be drunk unscrupulously.

 

In most European and American countries, the beginning and ending ages for colorectal cancer screening for general risk populations are between 50-75 years old.

People younger than 50 years old are not included in the screening range. Therefore, early-onset colorectal cancer is likely to be missed, and traditional Compared with colorectal cancer, it has the characteristics of a later stage and a worse prognosis .

 

Considering that the risk of colorectal cancer among young people is increasing year by year, some Western countries such as the United States suggest that the age of colonoscopy screening should be advanced from 50 to 45.

However, some experts believe that although the incidence of early-onset colorectal cancer has increased.

In fact, the number of patients is relatively small. Early screening of the age may lead to an overload of endoscopy and a waste of medical costs.

 

The age of onset of colorectal cancer in the Chinese population is 12-18 years younger than that in European and American countries.

Taking into account the national conditions of our country, it is recommended to receive colorectal cancer risk assessment from the age of 40 .

 

Young people in adolescence and adulthood are the main force in consuming sugar-sweetened beverages.

If the intake of sugar-sweetened beverages is not restricted, people in this era in the future are likely to suffer from obesity, diabetes, and cancer. Therefore, it is imperative to limit the intake of sugar-sweetened beverages.

 

 

 

 

References:

1.Hur J, Otegbeye E, Joh HK, et al. Sugar-sweetened beverage intake in adulthood and adolescence and risk of early-onset colorectal cancer among women. Gut. 2021;70(12):2330-2336.
2.Araghi M, Soerjomataram I, Bardot A, et al. Changes in colorectal cancer incidence in seven high-income countries: a population-based study [published correction appears in Lancet Gastroenterol Hepatol. 2019 Aug;4(8):e8] . Lancet Gastroenterol Hepatol. 2019;4(7):511-518.
3. Chen Wanqing, Li Ni, Lan Ping, Chen Hongda, Du Lingbin, Sun Feng, Li Guowei, He Xiaosheng, Wang Le, Li Ziyi, Zhu Chen, Lu Ming, Cao Maomao, Sun Dianqin, He Siyi, Li He, Yang Zhuoyu. Chinese colorectal cancer screen Guidelines for investigation and early diagnosis and treatment (2020, Beijing)[J].Chinese Cancer,2021,30(01):1-28.

500ml of sugary drinks per day doubles the risk of colorectal cancer!

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