Sitting for a long time greatly increases the risk of death for cancer patients

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Sitting for a long time greatly increases the risk of death for cancer patients

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JAMA Sub-Journal: Sitting for a long time greatly increases the risk of death for cancer patients.

According to the latest global cancer burden data released by the International Agency for Research on Cancer (IARC) of the World Health Organization [1], there will be approximately 19.29 million new cancer cases worldwide in 2020, and approximately 9.96 million new cancer deaths. Among them, there were 4.57 million new cancer cases in China and 3 million new cancer deaths.

Worldwide, as the population ages, the number of cancers will continue to increase.

In addition, overweight/obesity, sedentary, lack of exercise and other phenomena are becoming more and more common, which are also important factors causing the increase in the number of cancer incidences and deaths.

Recently, researchers from Washington University School of Medicine published a research paper in JAMA Oncolog, entitled Association of Daily Sitting Time and Leisure-Time Physical Activity With Survival Among US Cancer Survivors.

This prospective cohort study included 1,535 cancer survivors with a median follow-up time of 4.5 years.

The results found that people who have been sitting for longer have an increased risk of all-cause mortality, cancer mortality, and non-cancer mortality.

Those at the highest risk are those who do not exercise or are not active enough, and sit for more than 8 hours a day.

This result shows that sedentary and lack of exercise, which are very common among cancer patients, are associated with an increased risk of death.

Sedentary behavior, especially sedentary and lack of physical activity, may affect the survival of cancer patients.

Therefore, the research team hopes to study the relationship between the daily sedentary time and physical activity and mortality of cancer patients.

The research team used a prospective cohort of nationally representative cancer patient samples from the National Health and Nutrition Examination Survey of the United States from 2007 to 2014, including 1,535 cancer patients aged 40 years and over.

Correlate them with mortality data as of December 31, 2015, and analyze their daily sedentary time and leisure time physical activity.

Statistical analysis showed that among the 1535 cancer patients:

• 950 (56.8%)had zero physical activity time(no exercise) in a week ;
• 226 (15.6%) had physical activity less than 150 minutes/week (insufficient exercise) ;
• 359 people (27.6%) have physical activity greater than 150 minutes/week (active sports)
• 553 people (35.4%) sit for 6-8 hours a day
• 328 people (24.9%) sit for more than 8 hours a day.

It is worth noting that 574 people (35.8%) have little physical activity per week and also sit for more than 6 hours a day.

During the 9-year follow-up period (median follow-up time of 4.5 years) , a total of 293 people died of these 1535 people, of which 114 died of cancer, 41 died of heart disease, and the remaining 138 died of other causes .

The multivariate model showed that compared with non-exercise, exercise was associated with a reduction in the risk of all-cause death and cancer death.

Specifically, exercise was associated with a 66% reduction in their risk of all-cause death and a 68% reduction in the risk of cancer death.

Compared with people who sit for less than 4 hours a day, sitting for more than 8 hours a day is associated with an 81% increase in the risk of all-cause death and a 127% increase in the risk of cancer death.

These analyses show that sedentary and insufficient exercise are associated with a significantly increased risk of death for cancer patients.

Cancer patients who do not exercise or do not exercise enough and sit for more than 8 hours a day have the highest risk of all-cause death and cancer death, increasing by 438% and 371%, respectively.

In general, this cohort study of a nationally representative sample of cancer patients shows that sedentary and lack of exercise are very common, and this situation is related to their increased risk of all-cause death and cancer death.

Reference:
1.https://www.iarc.fr/faq/latest-global-cancer-data-2020-qa/
2.https://jamanetwork.com/journals/jamaoncology/article-abstract/2787951

Sitting for a long time greatly increases the risk of death for cancer patients

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