August 11, 2022

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Scientists grow embryos without Sperm Eggs and Uterus

Scientists grow embryos without Sperm Eggs and Uterus



 

Scientists grow embryos without Sperm Eggs and Uterus.

Can an embryo grow and develop without a uterus? It is not impossible.

Professor Jacob H. Hanna of the Weizmann Institute of Science and his research team made a “machine uterus”, successfully allowing mouse embryos to develop in it for 6 days, going through the key to the early gastrulation stage to the late stage of organogenesis stage.

The research results will be published in the top journal Nature in March 2021.

 

So if there are no sperm and eggs, can there be embryos? It is not impossible.

It was also Professor Jacob H. Hanna and his research team.

They directly constructed an embryo model from mouse primitive embryonic stem cells (ESCs) and cultured them in an in vitro “machine uterus” for 8 days. The embryo was completed.

The formation of gastrulation and the differentiation of specific progenitor cells in important organs such as the brain, neural tube, and heart are extremely similar in morphology and gene expression to naturally grown embryos.

This remarkable research result was also published in the top journal “Cell”.

It should not be an exaggeration to say that scientists have the superpower of “creating something out of nothing”?

 

Scientists grow embryos without Sperm Eggs and Uterus

 

 

From the very beginning of the experiment, the researchers had no idea of ​​using natural embryonic cells.

Primitive embryonic stem cells (ESCs) can be induced to differentiate into trophoblast stem cells (TSCs) and primitive endoderm cells (PrE), so theoretically, primitive embryonic stem cells can become the full source of embryonic and extraembryonic tissues.

As long as the method is appropriate, it may be possible to synthesize a complete embryo only by culturing the original embryonic stem cells in vitro.

 

This is the end of Professor Jacob H. Hanna’s “out of nothing” feat. Of course, he is full of confidence in the development of subsequent research.

 

 

Scientists grow embryos without Sperm Eggs and Uterus

Day 8 of culture vs. day 8.5 of natural embryo

 

 

Because the embryo’s in vitro culture device is transparent, they may be able to easily observe how exactly these embryonic cells find their place and assemble themselves into complete organs.

And synthetic embryos may become a reliable source of transplanted organs in the future, becoming a true “automatic 3D bioprinter”.

 

 

 

 

Scientists grow embryos without Sperm Eggs and Uterus

(source:internet, reference only)


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