Nature: Drinking freshly squeezed juice reduces immunity? 

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Nature: Drinking freshly squeezed juice reduces immunity? 

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Nature: Drinking freshly squeezed juice reduces immunity? 

Juice is often regarded as a very healthy drink, especially when compared with milk tea and cola, it appears healthy.

Juice is often regarded as a very healthy drink, especially when compared with milk tea and cola, it appears healthy. But in fact, juice is not as healthy as we think, and there is a big difference between juice and fruit. The juice squeezed out with a juicer has removed the solid part of the fruit and removed the precious dietary fiber of the fruit.

Fructose is usually found in sugary beverages, candies and processed foods. It is widely used in daily foods and is closely related to obesity, type 2 diabetes and non-alcoholic fatty liver. However, the relationship between high levels of fructose intake and the human immune system is unclear.

Recently, the researchers from British Swansea University published an article entitled” Fructose reprogrammes glutamine-dependent oxidative metabolism to support LPS-induced inflammation ” research paper on ” Nature Communications “

The study reveals the hazards of juice , The super high fructose in fruit juice will damage the body’s immune system, thereby causing the body’s immunity to decline .

Studies have shown that the increase in fructose content will accelerate the body’s oxidation, and it will also promote the secretion of some cytokines. These cytokines will further stimulate the body’s immune cells, resulting in various chronic inflammation symptoms, which will affect the body’s immune system. Produce further damage .

The research team used lipopolysaccharide to induce inflammation in human monocytes and mouse macrophages. Further studies have found that fructose exposure will reprogram cellular metabolic pathways to promote glutamine decomposition and oxidative metabolism. The increase in fructose-dependent mTORC1 activity will Drive the translation of pro-inflammatory cytokines in response to lipopolysaccharides.

In experiments with lipopolysaccharide-induced mouse systemic inflammation model, it was found that the level of lymphocyte stimulating factor (IL-1β) in the circulatory system of mice induced by fructose-induced lipopolysaccharide increased.

Fructose enhances inflammation when glucose is present in macrophages

The researchers compared glucose and fructose. In mice that added fructose to their diet, the function of macrophages in their bodies was affected, which promoted the occurrence of inflammation.

In short, a short-term high-content fructose beverage can promote the human body’s inflammatory response, showing pathological characteristics.

Not only that, a paper published in the top journal BMJ proved that sugar-sweetened beverages increase the risk of cancer. This study not only confirmed the carcinogenic risk of fruit juice, but also confirmed the carcinogenicity of all sugar-sweetened beverages .

The study included 101,257 participants aged 18 years or older and assessed the relationship between sugar-sweetened beverages, fruit juices, artificial sweetener beverages and cancer risk.

Studies have found that the overall cancer risk associated with sugar-sweetened beverages is 18% higher, and pure fruit juice will also increase the overall cancer risk by 12% .

It is particularly worth noting that the results of this study are less friendly to women who like to drink juice and milk tea . Breast cancer , which has now become the world’s largest cancer , is closely related to the intake of sugary beverages, and the risk is increased. 23% !

In order to satisfy the appetite, people have long made fruits into various sweets. In the process of making fruit juice, it will also lose its nutritional value such as cellulose, and there may be more potential risk factors, and it should no longer be regarded as a healthy drink.

From a health point of view, the World Health Organization recommends limiting your daily sugar intake to around 50 grams, or even better to 25 grams. However, we are still far from this goal.

Paper link:

https://doi.org/10.1038/s41467-021-21461-4

https://doi.org/10.1136/bmj.l2408

(source:internet, reference only)

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